| 476015-05-1

• CAS: 476015-05-1
• 化学式: C₄₄H₄₀ClFeNP₂Pd
• 分子量: 842.476
• InChiKey: SPVSIZZDVFMNQQ-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  1,1'-双(二苯基膦)二茂铁 、 [Pd(2-methylthiomethylpyridine)(1-(2,6-dimethylphenylimino)ethyl)Cl] 以 二氯甲烷 为溶剂， 生成
  参考文献：
  名称：

  钯(II)-亚氨基配合物：有机钯抗癌剂难题中的新篇章

  摘要：

  钯(II)-亚氨基配合物：有机钯抗癌剂难题中的新篇章。扩大了具有抗癌特性的有机钯化合物库。含有 PTA、DAPTA 和 dppf 膦的新型 Pd-亚氨基配合物在选择性和诱导细胞凋亡方面显示出对抗卵巢癌的有希望的结果。

  DOI：

  10.1002/ejic.202300673

文献信息

• Influence of Chelating Phosphines on the Insertion of Isocyanides into Palladium−Methyl Bonds in (P−P)Pd(Me)Cl Complexes and Their Further Reaction with Olefins and Isothiocyanates
  作者：Gareth R. Owen、Ramón Vilar、Andrew J. P. White、David J. Williams

  DOI：10.1021/om020444z

  日期：2002.10.1

  A systematic study of the insertion reactions between (P-P)Pd(Me)Cl (where P-P = dppe, dppp, dppf) and CNR (where R = 2,6-dimethylphenyl, tert-butyl) is presented. The results have demonstrated that the insertion of CNR into the Pd-Me bond is highly dependent on the nature of the chelating phosphine. For the more strained complex formed with dppe, the insertion of isocyanides is slower and multiple insertion is not observed. This is in contrast to (dppp)Pd(Me)Cl, which reacts readily with isocyanides to produce single-, double-, and multiple-inserted products. Results analogous to those of dppp have been observed for the complexes with dppf, although the reactions are more controllable, indicating a less reactive complex. In an attempt to establish some structure-reactivity correlations, structural characterizations of (dppe)PdC(Me)=NXyl}Cl (1) and (dppp)Pd(C=NXyl)(C(Me)=NXyl)}-Cl (3) have been carried out. The structural parameters obtained are consistent with the observed reactivity. The reactions between (dppe)PdC(Me)=NXyl}Cl and unsaturated (olefins and isothiocyanates) species have also been studied. While norbornadiene (a strained diolefin) inserts into the palladium-iminoacyl bond, an addition is observed when reacting 1 with isothiocyanates.