(2,2'-bipyridine)(3-(2-benzothiazolyl)-7-(diethylamino)coumarin)2Ir(1+)*PF6(1-) | 1410801-91-0

• 英文名称: (2,2'-bipyridine)(3-(2-benzothiazolyl)-7-(diethylamino)coumarin)2Ir(1+)*PF6(1-)
• 英文别名: Ir(coumarine 6)2(bpy)(1+)*PF6(1-)；(2,2'-bipyridine)(coumarine 6)2Ir(1+)*PF6(1-)；[Ir(coumarin 6)₂bpy]PF₆
• CAS: 1410801-91-0
• 化学式: C₅₀H₄₂IrN₆O₄S₂*F₆P
• 分子量: 1192.24
• InChiKey: FSQRTIGSHTZHKB-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  六氟磷酸钾 、 2,2'-联吡啶 、 di-μ-chlorido-bridged Ir(III) dimer of coumarin 6 以 甲醇 、 二氯甲烷 为溶剂， 以60 %的产率得到(2,2'-bipyridine)(3-(2-benzothiazolyl)-7-(diethylamino)coumarin)2Ir(1+)*PF6(1-)
  参考文献：
  名称：

  基于香豆素6为主配体的磷光铱(III)配合物的溶液加工橙色有机发光二极管

  摘要：

  以香豆素6为环金属配体，不同甲基数量和位置的2,2′-联吡啶(bpy)衍生物为辅助，成功合成了四种离子橙色磷光铱(III)配合物(Ir1、Ir2、Ir3、Ir4)配体。系统研究了辅助配体中取代基对其性能的影响。这四种配合物分别在590、588、587和586 nm波长处表现出橙色发射，在不同溶剂中具有优异的溶解度和显着的光物理性质。此外，它们还进一步应用于基于溶液法的有机发光二极管（OLED）。基于Ir1/Ir2/Ir3/Ir4的器件最大亮度达到1907.0/932.6/760.8/519.3 cd/m，并具有相应的最大电流效率（CE）、功率效率（PE）和外量子效率（EQE）值分别为 1.56/1.71/1.97/1.52 cd/A、0.33/0.32/0.35/0.27 lm/W 和 0.77/0.82/0.90/0.72 %。尽管OLED的性能还有改进的空间，但这种策略启发我们通过对其

  DOI：

  10.1016/j.jorganchem.2024.123088

文献信息

• 2‐Thiophenyl–Isoquinoline Ir(III) Complex: A Promising Tool in Antipseudomonal Photodynamic Therapy under Red Irradiation
  作者：Julien Renault、Julie Couchot、Aline L. Faucon、Jean‐Luc Renaud、Gaëtan L. A. Mislin、Patrick Plésiat、Sylvain Gaillard

  DOI：10.1002/ejic.202300767

  日期：2024.5.13

  Innovative therapeutic strategies are more than ever needed to counter the rise of antibiotic‐resistant bacterial pathogens worldwide. The use of light, and especially photodynamic therapy (PDT) appears as a promising alternative or complement to antibiotic treatments, fostered by the development of new photosensitizers. In this study, eight luminescent Ir(III) complexes were synthesized and evaluated for their photoactivation properties and capacity to generate radical species under blue (452 nm), green (525 nm), and red (631 nm) LED light, respectively. Their antibacterial properties were assessed on Pseudomonas aeruginosa, Acinetobacter baumannii, Escherichia coli, and Staphylococcus aureus with most of these complexes exhibiting potentially useful activities upon light irradiation, at concentrations below 10 mg/L. A complex of Ir(III) cyclometallated to thiophenyl‐isoquinoline (tiq) and bearing 2,2’‐bipyridine (bipy) as ancillary ligand was further investigated. This latter showed a concentration‐ and light intensity‐dependent bactericidal activity on P. aeruginosa when irradiated under blue to red lights, proving that such complexes would be suitable candidates for PDT. Importantly, this lead complex remained active against antibiotic resistant clinical strains and was unaffected by active efflux systems. These data open interesting perspectives for the development of new treatments to tackle antibiotic resistant Gram‐negative bacteria.