Pt(II)(cyclohexylamine)(ethylenediamine)Cl(NO3) | 1431632-66-4

• 英文名称: Pt(II)(cyclohexylamine)(ethylenediamine)Cl(NO3)
• 英文别名: Pt(II)(cyclohexylamine)(ethylenediamine)Cl(NO₃)；Pt(II)(cyclohexylamine)(en)Cl(NO₃)
• CAS: 1431632-66-4
• 化学式: C₈H₂₁ClN₃Pt*NO₃
• 分子量: 451.813
• InChiKey: UPMGDLJAGDEEJD-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  [Pt(ethylenediamine)(dimethylformamide)Cl](NO₃) 、 环己胺 以 5,5-dimethyl-1,3-cyclohexadiene 为溶剂， 生成 Pt(II)(cyclohexylamine)(ethylenediamine)Cl(NO3)
  参考文献：
  名称：

  Relative rates of reaction of Pt(en)Cl (NH2R)+ with guanosine monophosphate as a function of amino group substituent: Toward efficient labeling of DNA for TEM imaging

  摘要：

  In an attempt to understand the factors that govern the rates of reaction of the complexes [Pt(en) Cl(NH2R)]+NO3- (en = ethylene diamine) with guanosine monophosphate (dGMP) a series of amine complexes, where R=C8H9NO2 (benzo[d][1,3]dioxol-5-ylmethanamine) (1), C8H11N (phenethylamine) (2), C7H9N (benzylamine) (3), C6H7N (aniline) (4), C6H6IN (p-iodo-aniline) (5) C3H9NO (2-methoxyethylamine) (6) and C6H13N (cyclohexylamine) (7), were synthesized and their reactions with deoxyguanosine monophosphate (dGMP) were followed by H-1 NMR. Compound 1 was initially chosen because it showed significant water solubility. Compound 1 reacted quantitatively but slowly with dGMP and a subsequent Transmission Electron Microscopy (TEM) study of the binding 1 to a GATC DNA repeat gave a TEM micrograph that showed selective labeling of DNA at guanine, using a technique that allowed the laying down of a straight single strand of DNA on a carbon platform. The TEM suggested a possible side reaction with adenine and so a study of the reaction of 1 with adenine was performed and showed slow and what appeared to be non-specific binding to deoxyadenosine monophosphate (dAMP). The reactions of compounds 2-7 with dGMP were then studied by H-1 NMR and it was found that 2 reacted much faster than 1 with dGMP while the remaining complexes reacted more slowly. No reaction of 2 with dAMP was observed in the same time frame. The ultimate goal of the project was to bind a third row transition metal cluster to guanine and given the effective binding of 1 to DNA the synthesis of the complex [Os-3(CO)(11)PPh2(CH2)(2)NH2(en)PtCl]NO3 (9) is also reported that contains Pt as a linker to label guanine. The synthesis was performed by reacting Os-3(CO)(10)(CH3CN)(2) with Ph2PCH2CH2NH2 which gave an eta(2) chelate complex Os-3(CO)(10)PPh2(CH2)(2)NH2 (8). Complex 8 was reacted with [Pt(en)Cl(DMF)]NO3 in a CO atmosphere to give 9. H-1 and Pt-195 NMR indicate formation of an adduct with dGMP but too slowly to be of use in labeling DNA. The solid-state structure of 8 is also reported. (C) 2012 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jorganchem.2012.11.003