N,N'-bis-[2-((4-methyl-5-imidazolyl)methylthio)ethyl]urea | 55272-85-0

• 英文名称: N,N'-bis-[2-((4-methyl-5-imidazolyl)methylthio)ethyl]urea
• 英文别名: 1,3-bis[2-[(5-methyl-1H-imidazol-4-yl)methylsulfanyl]ethyl]urea
• CAS: 55272-85-0
• 化学式: C₁₅H₂₄N₆OS₂
• 分子量: 368.527
• InChiKey: XVJHAHSYUGHWDI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  24
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  149
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  N,N'-羰基二咪唑 、 2-(((5-甲基-1H-咪唑-4-基)甲基)硫代)乙胺 生成 N,N'-bis-[2-((4-methyl-5-imidazolyl)methylthio)ethyl]urea
  参考文献：
  名称：

  Certain thiazoles and oxazoles

  摘要：

  这些化合物是N,N'-取代硫脲、尿素和胍胺，它们是H-2组胺受体抑制剂。本发明的两种化合物是N,N'-双[2-((4-甲基-5-咪唑基)甲硫基)乙基]硫脲和N,N'-双[2-((4-甲基-5-咪唑基)甲硫基)乙基]-N"-氰基胍胺。

  公开号：

  US04025527A1

文献信息

• Imidazolyl thioureas, ureas and guanidines
  申请人：Smith Kline & French Laboratories Limited

  公开号：US04152443A1

  公开（公告）日：1979-05-01

  The compounds are N,N' -substituted thioureas, ureas and guanidines which are H-2 histamine receptor inhibitors. Two compounds of this invention are N,N'-bis[2-((4-methyl-5-imidazolyl)methylthio)ethyl] thiourea and N,N'-bis[2-((4-methyl-5-imidazolyl)methylthio)ethyl]-N"-cyanoguanidine.

  这些化合物是N，N'-取代硫脲，脲和鸟氨酸，它们是H-2组胺受体抑制剂。本发明的两种化合物是N，N'-双[2-（（4-甲基-5-咪唑基）甲基硫基）乙基]硫脲和N，N'-双[2-（（4-甲基-5-咪唑基）甲基硫基）乙基]-N''-氰基鸟氨酸。
• N-Heterocyclic alkyl-N'-thiadiazolyl, thiazolyl and isothiazolyl
  申请人：Smith Kline & French Laboratories Limited

  公开号：US04388319A1

  公开（公告）日：1983-06-14

  The compounds are N,N'-substituted thioureas, ureas and guanidines which are H-2 histamine receptor inhibitors. A compound of this invention is N-cyano-N'-[2-((4-methyl-5-imidazolyl)methylthio)ethyl]-N"-[2-(2-thiazolyl methylthio)ethyl]guanidine.

  这些化合物是N,N'-取代硫脲、脲和鸟氨酸类物质，它们是H-2组胺受体抑制剂。该发明的一种化合物是N-氰基-N'-[2-((4-甲基-5-咪唑基)甲硫基)乙基]-N"-[2-(2-噻唑甲硫基)乙基]鸟氨酸。
• Pyridyl ureas, thioureas and guanidines
  申请人：Smith Kline & French Laboratories Limited

  公开号：US04215125A1

  公开（公告）日：1980-07-29

  The compounds are N,N'-substituted thioureas, ureas and guanidines which are H-2 histamine receptor inhibitors. A compound of this invention is N,N'-bis-[2-(2-pyridylmethylthioethyl]-N"-cyanoguanidine.

  这些化合物是N,N'-取代硫脲、尿素和鸟氨酸，它们是H-2组胺受体抑制剂。该发明的一种化合物是N,N'-双-[2-(2-吡啶甲基硫乙基)]-N''-氰基鸟氨酸。
• Pharmacologically active isoxazole and triazole compounds
  申请人：Smith Kline & French Laboratories Limited

  公开号：US04499101A1

  公开（公告）日：1985-02-12

  The compounds are N,N'-substituted thioureas, ureas and guanidines which are H-2 histamine receptor inhibitors. Two compounds of this invention are N,N'-bis[2-((4-methyl-5-imidazolyl)methylthio)ethyl]thiourea and N,N'-bis[2-((4-methyl-5-imidazolyl)methylthio)ethyl]-N"-cyanoguanidine.

  这些化合物是N，N'-取代硫脲，脲和鸟氨酸，它们是H-2组胺受体抑制剂。本发明的两种化合物是N，N'-双[2-（（4-甲基-5-咪唑基）甲硫基）乙基]硫脲和N，N'-双[2-（（4-甲基-5-咪唑基）甲硫基）乙基]-N''-氰基鸟氨酸。
• N-Heterocyclic alkyl-N'-pyridyl alkylthioureas, ureas and guanidines
  申请人：Smith Kline & French Laboratories Limited

  公开号：US04271169A1

  公开（公告）日：1981-06-02

  The compounds are N,N'-substituted thioureas, ureas and guanidines which are H-2 histamine receptor inhibitors. A compound of this invention is N-[2-(2-pyridylmethylthio)ethyl]-N'-[2-(4-methyl-5-imidazolylmethylthio)et hyl]thiourea is N,N'-bis[2-((4-methyl-5-imidazolyl)methylthio)ethyl]thiourea and N,N'-bis[2-((methyl-5-imidazolyl)methylthio)ethyl]-N"-cyanoguanidine.

  这些化合物是N，N'-取代硫脲，尿素和鸟氨酸，它们是H-2组胺受体抑制剂。本发明的一种化合物是N-[2-(2-吡啶甲基硫基)乙基]-N'-[2-(4-甲基-5-咪唑甲基硫基)乙基]硫脲，是N，N'-双[2-((4-甲基-5-咪唑基)甲基硫基)乙基]硫脲和N，N'-双[2-((甲基-5-咪唑基)甲基硫基)乙基]-N''-氰基鸟氨酸。