5-butyl-2,2-diphenylfuran-3(2H)-one | 1046785-82-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氢呋喃
• 英文名称: 5-butyl-2,2-diphenylfuran-3(2H)-one
• CAS: 1046785-82-3
• 化学式: C₂₀H₂₀O₂
• 分子量: 292.378
• InChiKey: DYLUSUIIZYCIIA-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  2-hydroxy-1,2-diphenyl-3-yn-1-one 在 platinum(II) chloride 作用下， 以 甲苯 为溶剂， 反应 8.0h， 以77%的产率得到5-butyl-2,2-diphenylfuran-3(2H)-one
  参考文献：
  名称：

  Pt-catalyzed cyclization/migration of propargylic alcohols for the synthesis of 3(2H)-furanones, pyrrolones, indolizines, and indolizinones

  摘要：

  Several heterocycles such as furanones, pyrrolones, and indolizines, which are of pharmacological importance, are easily accessed via the Pt(II)-catalyzed heterocyclization/1,2-migration of propargylic ketols or hydroxy imine derivatives. This method sidesteps the challenges of traditional heteroaromatic oxygenation strategies such as regioselectivity and functional group tolerance in the syntheses of these heterocycles. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.02.103