1,3-bis(chlorido[3-(oxo-κO)-2-methyl-4-pyridinonato-κO4](η6-p-isopropyltoluene)ruthenium(II))propane | 1016582-98-1

• 英文名称: 1,3-bis(chlorido[3-(oxo-κO)-2-methyl-4-pyridinonato-κO4](η6-p-isopropyltoluene)ruthenium(II))propane
• CAS: 1016582-98-1
• 化学式: C₃₅H₄₄Cl₂N₂O₄Ru₂
• 分子量: 829.791
• InChiKey: MBWWGZNXEQHAIC-UHFFFAOYSA-J

反应信息

• 作为产物：
  描述：

  [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂ 、 1,3-bis(3-hydroxy-2-methyl-4-pyridinon-1-yl)propane 在 sodium methylate 作用下， 以 甲醇 为溶剂， 以75%的产率得到1,3-bis(chlorido[3-(oxo-κO)-2-methyl-4-pyridinonato-κO4](η6-p-isopropyltoluene)ruthenium(II))propane
  参考文献：
  名称：

  Influence of the Spacer Length on the in Vitro Anticancer Activity of Dinuclear Ruthenium−Arene Compounds

  摘要：

  Water-soluble dinuclear Ru-arene complexes were synthesized and found to exert promising cytotoxic effects in human cancer cells, which could be increased to an IC50 of 0.29 mu M by increasing the spacer length between the metal centers. Cytotoxicity could be correlated with lipophilicity (log P values) and water solubility. The most potent dinuclear compound, 1,12-bis{chlorido[3-(oxo-kappa O)-2-methyl-4-pyridinonato-kappa O4](eta(6)-p-isopropyltoluene)ruthenium}dodecane, is at least 2-3 orders of magnitude more active than the mononuclear analogue chlorido[3-(oxo-kappa O)-2-methyl-4-pyronato-kappa O4](eta(6)-p-isopropyltoluene)-ruthenium.

  DOI：

  10.1021/om800207t