(4-acetamidophenyl)diphenylphosphine | 106865-18-3

• 英文名称: (4-acetamidophenyl)diphenylphosphine
• 英文别名: 4-(diphenylphosphino)acetanilide；N-(4-diphenylphosphanylphenyl)acetamide
• CAS: 106865-18-3
• 化学式: C₂₀H₁₈NOP
• 分子量: 319.343
• InChiKey: LKDCGEXTADLQRP-UHFFFAOYSA-N

物化性质

• 熔点：
  117-119 °C
• 沸点：
  487.4±28.0 °C(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (4-acetamidophenyl)diphenylphosphine 在 双氧水 作用下， 以 乙醇 为溶剂， 反应 0.17h， 以68%的产率得到N-[4-(diphenylphosphinyl)phenyl]acetamide
  参考文献：
  名称：

  N-Aryl-3,3,3-trifluoro-2-hydroxy-2-methylpropanamides:  K_ATP Potassium Channel Openers. Modifications on the Western Region

  摘要：

  A subset of antiandrogen compounds, the N-aryl-3,3,3-trinuoro-2-hydroxy-2-methylpropanamides 1, were found to activate ATP sensitive potassium channels (K-ATP) and represent a new class of potassium channel openers (PCOs). A structure-activity relationship was carried out on the western region of this series with the goal of obtaining an activator of the ATP sensitive potassium channel suitable for use in the treatment of urge urinary incontinence. In particular three large 4-(N-aryl) substituents, the (N-phenyl-N-methylamino)sulfonyl, benzoyl, and 4-pyridylsulfonyl moieties, yielded non-antiandrogen, K-ATP potassium channel openers (39, 41, and 64, respectively) that are bladder selective in an in vivo rat model that simultaneously measures bladder contractions, heart rate, and blood pressure. Substitutions of the aryl rings of 41 and 64 gave several derivatives that also display selectivity in the in vivo rat model; however, none appear to offer a substantial advantage over 41 and 64. The PCO activity of 41 and 64 resides in the (S)-(-) enantiomers. ZD6169, 41(S), has been selected into development for the treatment of urge urinary incontinence.

  DOI：

  10.1021/jm960365n
• 作为产物：
  描述：

  三苯基膦 在 双(乙腈)氯化钯(II) 、 lithium 作用下， 以 苯 为溶剂， 反应 24.0h， 生成 (4-acetamidophenyl)diphenylphosphine
  参考文献：
  名称：

  Palladium-catalyzed coupling of aryl halides with (trimethylstannyl)diphenylphosphine and (trimethylsilyl)diphenylphosphine

  摘要：

  DOI：

  10.1021/jo00381a008

文献信息

• Anion-assisted trans–cis isomerization of palladium(<scp>ii</scp>) phosphine complexes containing acetanilide functionalities through hydrogen bonding interactions
  作者：Xiao-Xia Lu、Hau-San Tang、Chi-Chiu Ko、Jenny Ka-Yan Wong、Nianyong Zhu、Vivian Wing-Wah Yam

  DOI：10.1039/b418202b

  日期：——

  The anion-assisted shift of trans-cis isomerization equilibrium of a palladium(II) complex containing acetanilide functionalities brought about by allosteric hydrogen bonding interactions has been established by UV/Vis, 1H NMR, 31P NMR and ESI-MS studies.

  已通过UV / Vis，1H NMR，31P NMR和ESI-MS研究确定了由变构氢键相互作用引起的含有乙酰苯胺官能团的钯（II）配合物的反式-顺式异构化平衡的阴离子辅助转移。
• TUNNEY S. E.; STILLE J. K., J. ORG. CHEM., 52,(1987) N 5, 748-753
  作者：TUNNEY S. E.、 STILLE J. K.

  DOI：——

  日期：——