2-(N-(2-(((9H-fluoren-9-yl)methoxy)carbonylamino)ethyl)-2-(5-(N-ferrocenylbenzamido)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamido)acetic acid | 1053242-06-0

• 英文名称: 2-(N-(2-(((9H-fluoren-9-yl)methoxy)carbonylamino)ethyl)-2-(5-(N-ferrocenylbenzamido)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamido)acetic acid
• CAS: 1053242-06-0
• 化学式: C₄₃H₃₉FeN₅O₈
• 分子量: 809.658
• InChiKey: VGZMICKSIBTTLX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  tert-butyl-2-(N-(2-(((9H-fluoren-9-yl)methoxy)carbonylamino)ethyl)-2-(5-(N-ferrocenylbenzamido)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamido)acetate 、 9-芴甲基-N-琥珀酰亚胺基碳酸酯 在 sodium hydroxide 、 碳酸氢钠 、 柠檬酸 作用下， 以 水 、 丙酮 为溶剂， 以38%的产率得到2-(N-(2-(((9H-fluoren-9-yl)methoxy)carbonylamino)ethyl)-2-(5-(N-ferrocenylbenzamido)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamido)acetic acid
  参考文献：
  名称：

  Synthesis of a ferrocenyl uracil PNA monomer for insertion into PNA sequences

  摘要：

  The deprotection of the tert-butyl group of a ferrocenyl uracil Peptide Nucleic Acid (PNA) monomer, Fmoc-aeg(R)-OtBu (1) was achieved using a two step synthesis involving hydrolysis in basic conditions to give first the zwitterion of +NH3-aeg(R)-O (7). Compound 7 was reacted in situ with N-(9-fluorenylmethoxycarbonyloxy) succinimide to obtain the expected compound Fmoc-aeg(R)-OH (2) (Abbreviations: Aeg = (2-aminoethyl)-glycine; Fmoc = 9-fluorenylmethoxycarbonyl; OtBu = tert-butyl; R = 5-(N-ferrocenylmethylbenzamido) uracyl). Crown Copyright (C) 2008 Published by Elsevier B. V. All rights reserved.

  DOI：

  10.1016/j.jorganchem.2008.05.009