[(PizDTC)Au₂Cl₄] | 1428789-06-3

• 英文名称: [(PizDTC)Au₂Cl₄]
• 英文别名: [(piperazinedithiocarbamate)Au₂Cl₄]
• CAS: 1428789-06-3
• 化学式: C₆H₈Au₂Cl₄N₂S₄
• 分子量: 772.152
• InChiKey: YUYFJPAWXWSKPS-UHFFFAOYSA-H

反应信息

• 作为产物：
  描述：

  sodium piperazine-N,N'-bisdithiocarboxylate 、 potassium tetrachloroaurate(III) dihydrate 以 水 为溶剂， 反应 2.0h， 以70.1%的产率得到[(PizDTC)Au₂Cl₄]
  参考文献：
  名称：

  Synthesis, characterization and cytotoxicity of the Au(III) complexes with cyclic amine-based dithiocarbamate ligands

  摘要：

  Seven new Au(III) complexes ([(PipDTC)AuCl2] (1), [(MoDTC)AuCl2] (2), [(BzoPizDTC)AuCl2] (3), [(TsPizDTC) AuCl2] (4), [(PizDTC)Au2Cl4] (5), [(MePizDTC)Au2Cl5] (6) and [(EtPizDTC)Au2Cl5] (7)) with cyclic amine-based dithiocarbamate have been synthesized, characterized and evaluated in vitro. The results indicate that these complexes exert selective cytotoxic effects against HL-60, BGC-823, Bel-7402 and KB cells lines. Complex 1 shows 11-, 5- and 1-folds higher cytotoxicity than cisplatin against KB, BGC-823 and Bel-7402 cell lines. Complex 2 exhibits higher cytotoxicity than cisplatin against BGC-823 and Bel-7402 cell lines. Complexes 3 and 4 display higher cytotoxicity than cisplatin against BGC-823 cell line. The nature of cyclic amine and the number of metal centers have important effects on cytotoxicity of these Au(III) complexes. (C) 2013 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.inoche.2013.02.010