1-(3-{2-[4-(2-Bromo-5-methoxybenzyl)-1-piperidinyl]ethyl}phenyl)ethanol | 391956-20-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-(3-{2-[4-(2-Bromo-5-methoxybenzyl)-1-piperidinyl]ethyl}phenyl)ethanol
• 英文别名: 1-[3-[2-[4-[(2-Bromo-5-methoxyphenyl)methyl]piperidin-1-yl]ethyl]phenyl]ethanol
• CAS: 391956-20-0
• 化学式: C₂₃H₃₀BrNO₂
• 分子量: 432.401
• InChiKey: CJXPSKKSQROJPA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  27
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  32.7
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Serotonin reuptake inhibitor
  申请人：SUMITOMO PHARMACEUTICALS COMPANY LIMITED

  公开号：US20030191126A1

  公开（公告）日：2003-10-09

  A serotonin reuptake inhibitor containing a cyclic amine represented by the following formula, a prodrug thereof, or a pharmaceutically acceptable salt of said cyclic amine or prodrug as an active ingredient: 1 wherein R 0 is a hydrogen atom, a halogen atom, an alkyl group, a substituted alkyl group, a hydroxyl group, an alkoxy group or the like, R 3 is a hydrogen atom or the like, Y is an alkylene group or the like, Z is a hydrogen atom, a cycloalkyl group, an aryl group or the like, n is 1, 2 or 3, and m is 2, 3, 4, 5 or 6.

  一种含有下列公式所代表的环胺的5-羟色胺再摄取抑制剂，其前药，或所述环胺或前药的药用可接受的盐作为活性成分：其中R0是氢原子、卤原子、烷基、取代烷基、羟基、烷氧基或类似物，R3是氢原子或类似物，Y是烷基或类似物，Z是氢原子、环烷基、芳基或类似物，n为1、2或3，m为2、3、4、5或6。
• SEROTONIN REUPTAKE INHIBITORS
  申请人：Sumitomo Pharmaceuticals Company, Limited

  公开号：EP1304324A1

  公开（公告）日：2003-04-23

  A serotonin reuptake inhibitor containing a cyclic amine represented by the following formula, a prodrug thereof, or a pharmaceutically acceptable salt of said cyclic amine or prodrug as an active ingredient: wherein R0 is a hydrogen atom, a halogen atom, an alkyl group, a substituted alkyl group, a hydroxyl group, an alkoxy group or the like, R3 is a hydrogen atom or the like, Y is an alkylene group or the like, Z is a hydrogen atom, a cycloalkyl group, an aryl group or the like, n is 1, 2 or 3, and m is 2, 3, 4, 5 or 6.

  一种血清素再摄取抑制剂，其活性成分含有下式所代表的环胺、其原药或所述环胺或原药的药学上可接受的盐： 其中 R0 是氢原子、卤素原子、烷基、取代烷基、羟基、烷氧基或类似物，R3 是氢原子或类似物，Y 是亚烷基或类似物，Z 是氢原子、环烷基、芳基或类似物，n 是 1、2 或 3，m 是 2、3、4、5 或 6。
• US6787560B2
  申请人：——

  公开号：US6787560B2

  公开（公告）日：2004-09-07