3,5-(2,5-dioxopyrrolidin-1-yl 2-dithioacetate)-3a,4a-diaza-4,4-difluoro-8-phenyl boron dipyrromethene | 1206782-92-4

• 英文名称: 3,5-(2,5-dioxopyrrolidin-1-yl 2-dithioacetate)-3a,4a-diaza-4,4-difluoro-8-phenyl boron dipyrromethene
• CAS: 1206782-92-4
• 化学式: C₂₇H₂₁BF₂N₄O₈S₂
• 分子量: 642.426
• InChiKey: QBAFMKALCUYEDN-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  N-羟基丁二酰亚胺 、 3,5-dithioacetic acid-3a,4a-diaza-4,4-difluoro-8-phenyl boron dipyrromethene 在 N,N'-二环己基碳二亚胺 作用下， 以 乙腈 为溶剂， 以67%的产率得到3,5-(2,5-dioxopyrrolidin-1-yl 2-dithioacetate)-3a,4a-diaza-4,4-difluoro-8-phenyl boron dipyrromethene
  参考文献：
  名称：

  Synthesis, spectroscopic properties and protein labeling of water soluble 3,5-disubstituted boron dipyrromethenes

  摘要：

  Sulfur-containing 3,5-disubstituted boron dipyrromethene (Bodipy (R)) fluorescent probes with improved water solubility were synthesized. A dicarboxylic acid derivative that can be excited by the 543 nm HeNe laser line is very soluble in aqueous solution and retains high fluorescence quantum yield of the unionizable parent molecule. Conversion of the dicarboxylic acid to the succimidyl or sulfosuccinimidyl diester produces molecules capable of labeling proteins with a bright and stable fluorescence signal. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.10.080