(α-ferrocenyl-p-tolylaminomethyl)diphenylphosphine oxide | 918423-19-5

• 英文名称: (α-ferrocenyl-p-tolylaminomethyl)diphenylphosphine oxide
• CAS: 918423-19-5
• 化学式: C₃₀H₂₈FeNOP
• 分子量: 505.379
• InChiKey: JBWICNJVJKTMQB-KHZPMNTOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  [(η(5)-C5H5)Fe(η(5)-C5H4-C(H)=N-C6H4-4-CH3)] 、 水 、 二苯基膦酸锂 以 四氢呋喃 为溶剂， 以68%的产率得到(α-ferrocenyl-p-tolylaminomethyl)diphenylphosphine oxide
  参考文献：
  名称：

  Synthesis, characterization and the crystal structures of novel achiral and chiral α-ferrocenyl α-aminophosphine oxides

  摘要：

  Novel achiral alpha-ferrocenyl alpha-aminophosphine oxides (2a-2e) have been prepared by the reaction of ferrocenylaldimines (1a-1e) with Ph2PLi at room temperature in 63-92% yield. Similarly, starting from L-phenylalaninol derived ferrocenylaldimine (3), the corresponding (S,S)-phosphine oxide (4) and its (R,S)-diastereomer (5) were isolated by fractional crystallization in 41% and 16% yield, respectively. All the achiral and chiral alpha-aminophosphine oxides were air-stable and easily accessible. They were fully characterized by elemental analysis, H-1 NMR, P-31 NMR and IR spectra. In addition, structures of 2e and 4 have been determined by X-ray single-crystal analysis. (C) 2006 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.inoche.2006.02.027