cis-[(PPh3)2Pt(9-methyadenine(-H),N6,N7)][PF6] | 1020734-45-5

• 英文名称: cis-[(PPh3)2Pt(9-methyadenine(-H),N6,N7)][PF6]
• 英文别名: cis-[(PPh3)2Pt(9-MeAd(-H),N6,N7)][PF6]
• CAS: 1020734-45-5
• 化学式: C₄₂H₃₆N₅P₂Pt*F₆P
• 分子量: 1012.77
• InChiKey: SVIQAZVCHVALHZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  9-甲基腺嘌呤 、 cis-[(PPh3)2Pt(μ-OH)]2[PF6]2 以 N,N-二甲基甲酰胺 为溶剂， 以77%的产率得到cis-[(PPh3)2Pt(9-methyadenine(-H),N6,N7)][PF6]
  参考文献：
  名称：

  Synthesis and characterization of cis-[(PPh3)2Pt{9-MeAd(-H),N6N7}]X (X−= NO3, PF6): The first example of a platinum(II) complex containing the N6,N7-chelated 9-methyladenine anion

  摘要：

  Reaction between the binuclear hydroxo complex cis-[( PPh3)(2)Pt(mu-OH)](2)X-2 (X-=NO3, 1a; PF6-, 1b) and the model DNA base 9methyladenine (9-MeAd) leads to the formation of the mononuclear species cis-[( PPh3)(2)Pt{9-MeAd(-H),(NN7)-N-6}] X ( X-=NO3, 2a; PF6, 2b), in which the nucleobase chelates the Pt( II) ion with the N6 and N7 atoms. The coordination mode of the nucleobase has been determinated through a multinuclear (H-1, P-31, C-13, N-15 and Pt-195) NMR analysis and the nuclearity of the complex has been obtained by E. S. I. mass spectrometry. 2 represents the first example of an isolated platinum complex in which the NH2- deprotonated adenine exhibits this binding mode. (C) 2007 Elsevier B. V. All rights reserved.

  DOI：

  10.1016/j.ica.2007.02.025

文献信息

• Synthesis, characterization, structures and in vitro antitumor activity of platinum(II) complexes bearing adeninato or methylated adeninato ligands
  作者：Karoline Mueller、Christina Schütz、Tobias Rüffer、Martin Bette、Goran N. Kaluđerović、Dirk Steinborn、Harry Schmidt

  DOI：10.1016/j.ica.2020.119539

  日期：2020.7

  Abstract Reactions of the carbonato platinum(II) complexes [Pt(CO3)(PPh3)2]·CH2Cl2 (1) and [Pt(CO3)(dppe)] (dppe = 1,2-bis(diphenylphosphino)ethane; 2) with adenine (3a) and its N6-methylated derivatives (N6-MeAde, 3b; N6,N6-Me2Ade, 3c) resulted under splitting off carbon dioxide in formation of bis(adeninato)platinum complexes [Pt(N6,N6-RR’Ade–H-κN9)2(PPh3)2] (4a–4c) and [Pt(N6,N6-RR’Ade–H-κN9)2(dppe)]

  羰基铂（II）络合物[Pt（CO3）（PPh3）2]·CH2Cl2（1）和[Pt（ ）（dppe）]的反应（dppe = 1,2-双（二苯基膦基）乙烷; 2）与腺嘌呤（3a）及其N6-甲基化衍生物（N6-MeAde，3b; N6，N6-Me2Ade，3c）在分离二氧化碳的作用下形成了双（腺嘌呤）铂络合物[Pt（N6，N6-RR' Ade–H-κN9）2（PPh3）2]（4a–4c）和[Pt（N6，N6-RR'Ade–H-κN9）2（dppe）]（5a–5c）R / R'= H，我，分别。与在N9或N3位置甲基化的腺嘌呤（9-MeAde，3d; N6,9-Me2Ade，3e; 3-MeAde，3f）发生的类似反应产生阳离子络合物，可以将其分离为六氟磷酸盐：[Pt（9-MeAde– H-κ2N6，N7）（PPh3）2] [PF6]（6a），[Pt（N6,9-Me2Ade–H-κ2N6，N7）（dppe）]