(OC-6-14)-dichlorobis(dimethyl sulfoxide)(6-(E)-[(α-picolyl-κN)imino-κN]-7,12-dihydroindolo[3,2-d][1]benzazepine)ruthenium(II) | 936742-77-7

• 英文名称: (OC-6-14)-dichlorobis(dimethyl sulfoxide)(6-(E)-[(α-picolyl-κN)imino-κN]-7,12-dihydroindolo[3,2-d][1]benzazepine)ruthenium(II)
• CAS: 936742-77-7
• 化学式: C₂₆H₃₀Cl₂N₄O₂RuS₂
• 分子量: 666.658
• InChiKey: FSYIKKHGPNQAQV-UHFFFAOYSA-L

反应信息

• 作为产物：
  描述：

  dichlorotetrakis(dimethylsulfoxide)ruthenium 、 6-(α-picolylamino)-7,12-dihydroindolo[3,2-d][1]benzazepine 以 乙醇 为溶剂， 以26%的产率得到(OC-6-14)-dichlorobis(dimethyl sulfoxide)(6-(E)-[(α-picolyl-κN)imino-κN]-7,12-dihydroindolo[3,2-d][1]benzazepine)ruthenium(II)
  参考文献：
  名称：

  The First Ruthenium-Based Paullones:  Syntheses, X-ray Diffraction Structures, and Spectroscopic and Antiproliferative Properties in Vitro

  摘要：

  Two novel paullone derivatives, namely, 6-(alpha-picolylamino)-7,12-dihydroindolo[3,2-d][1]benzazepine (L-1) and 9-bromo-6-(alpha-picolylamino)-7,12-dihydroindolo[3,2-d][1]benzazepine (L-2), have been prepared. The reaction of cis-[RuCl2(DMSO)(4)] (DMSO = dimethyl sulfoxide) with L-1 and L-2 in a 1:1 molar ratio in dry ethanol at 50 degrees C afforded the complexes trans-[(RuCl2)-Cl-II(DMSO)(2)L-1] (1a) and trans-[(RuCl2)-Cl-II(DMSO)(2)L-2] (1b) in 26 and 30% yield, respectively. The reaction carried out from the same starting compounds in a 1:2 molar ratio at 75 degrees C led to the formation of [(RuCl)-Cl-II(DMSO)(L-1)(2)]Cl (2a) and [(RuCl)-Cl-II(DMSO)(L-2)(2)]Cl (2b) in 16 and 23% yield, correspondingly. The products were characterized by elemental analysis, one- and two-dimensional NMR spectroscopy, electrospray ionization mass spectrometry, IR spectroscopy, electronic spectra, cyclic voltammetry, and X-ray crystallography (L-1, L-2, 1a, and 2b). Complexes 2a and 2b exhibit remarkable antiproliferative activity in three human carcinoma cell lines, A549 (non-small cell lung carcinoma), CH1 (ovarian carcinoma), and SW480 (colon carcinoma). The novel complexes show an intercalative mode of interaction with DNA, which may render them attractive alternatives to metal compounds with a coordinative mode of interaction.

  DOI：

  10.1021/ic070098j