(C5H4C(O)CH3)(99m)Tc(CO)3 | 139410-50-7

• 英文名称: (C5H4C(O)CH3)(99m)Tc(CO)3
• CAS: 139410-50-7
• 化学式: C₁₀H₇O₄Tc
• 分子量: 290.163
• InChiKey: IEXCOFGNDPMNFA-RCUQKECRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
  None
• 氢给体数：
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• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  (C5H4C(O)CH3)(99m)Tc(CO)3 、 3-(4-dimethylamino-phenyl)-propenal 在 sodium hydroxide 作用下， 以 乙醇 为溶剂， 反应 0.5h， 生成
  参考文献：
  名称：

  Novel Cyclopentadienyl Tricarbonyl Complexes of ^99mTc Mimicking Chalcone as Potential Single-Photon Emission Computed Tomography Imaging Probes for β-Amyloid Plaques in Brain

  摘要：

  Rhenium and technetium-99m cyclopentadienyl tricarbonyl complexes mimicking the chalcone structure were prepared. These complexes were proved to have affinity to beta-amyloid (A beta) in fluorescent staining on brain sections of Alzheimer's Disease (AD) patient and binding assay using A beta(1-42) aggregates, with K-i values ranging from 899 to 108 nM as the extension of conjugated pi system. In vitro autoradiograpy on sections of transgenic mouse brain confirmed the affinity of [Tc-99m]5 (K-i = 108 nM). In biodistribution, all compounds showed good initial uptakes into the brain and fast blood clearance, while the decreasing of initial brain uptakes correspond to increasing of conjugation length, from 4.10 +/- 0.38% ID/g ([Tc-99m]3) to 1.11 +/- 0.34% ID/g ([Tc-99m]5). These small technetium-99m complexes (<500 Da) designed by an integrated approach provide encouraging evidence that development of a promising Tc-99m-labeled agent for imaging A beta plaques in the brain may be feasible.

  DOI：

  10.1021/jm3014184
• 作为产物：
  描述：

  fac-triaquatricarbonyltechnetium-99m(1+) 、 sodium acetylcyclopentadiene 在 phosphate buffer 作用下， 以 水 为溶剂， 以40%的产率得到(C5H4C(O)CH3)(99m)Tc(CO)3
  参考文献：
  名称：

  Aqueous One-Pot Synthesis of Derivatized Cyclopentadienyl-Tricarbonyl Complexes of99mTc with an In Situ CO Source: Application to a Serotonergic Receptor Ligand

  摘要：

  Instant radiopharmaceuticals-just add [(99m) TcO4 ](-) in water! Half-sandwich complexes of the type [(RCOCp)(99m) Tc(CO)3 ] (e.g. 1) were synthesized in a single step in water from [(99m) TcO4 ](-) . The acidification of the Cp ring by a carbonyl substituent and the use of K2 [H3 BCO2 ] as a reducing agent and in situ source of CO are instrumental in the synthesis.

  DOI：

  10.1002/1521-3773(20010817)40:16<3062::aid-anie3062>3.0.co;2-o