hexacarbonyl[μ-η4-(methyl 4-(2-methoxy-5-methylphenyl)-2-butynoate)]dicobalt | 1189570-80-6

• 英文名称: hexacarbonyl[μ-η4-(methyl 4-(2-methoxy-5-methylphenyl)-2-butynoate)]dicobalt
• CAS: 1189570-80-6
• 化学式: C₁₉H₁₄Co₂O₉
• 分子量: 504.301
• InChiKey: YXVOQQDEDSQAIY-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  hexacarbonyl[μ-η4-(methyl 4-(2-methoxy-5-methylphenyl)-2-butynoate)]dicobalt 在 碘 作用下， 以 四氢呋喃 为溶剂， 反应 10.0h， 以97%的产率得到methyl 4-(2-methoxy-5-methylphenyl)-2-butynoate
  参考文献：
  名称：

  The Synthesis of Velloziolide via Nicholas Reaction Based γ-Carbonyl Cations

  摘要：

  The total synthesis of the 9,11-seco-rosane diterpene velloziolide (1) has been accomplished by employing the Nicholas reaction chemistry of 2a as a gamma-carbonyl cation equivalent. An initial model Study demonstrated the utility of Nicholas reactions of 2 in the generation of 4-arylalkynoate Co(2)(CO)(6) complexes, and in conjunction with Gilman cuprate addition and Johnson-Claisen rearrangement chemistry, the preparation of a 3-methyl-3-vinyl-4-arylalkanoate model for velloziolide. The Nicholas reaction/gamma-carbonyl cation methodology was then employed twice in the total synthesis to incorporate onto 3,4-methylenedioxytoluene the 4-carbon unit that became the gem-dimethyltetralin portion of the velloziolide and, subsequently, to incorporate the gamma-arylalkanoate function of the epsilon-lactone.

  DOI：

  10.1021/jo901471b