trans-[PtCl2(E-N(H)=C(NMe2)CH2Ph)2] | 1054659-38-9

• 英文名称: trans-[PtCl2(E-N(H)=C(NMe2)CH2Ph)2]
• CAS: 1054659-38-9；1053263-44-7
• 化学式: C₂₀H₂₈Cl₂N₄Pt
• 分子量: 590.455
• InChiKey: FHGBOHQLVSYVEO-YFQJWWFYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  trans-{Pt(C6H5CH2CN)2Cl2} 、 二甲胺 以 四氢呋喃 、 二氯甲烷 为溶剂， 以87%的产率得到trans-[PtCl2(E-N(H)=C(NMe2)CH2Ph)2]
  参考文献：
  名称：

  Benzylamidine complexes of platinum(II) derived by nucleophilic addition of primary and secondary amines. X-ray crystal structure of trans-[PtCl2{Z-N(H)C(NHMe)CH2Ph}2]

  摘要：

  The reaction of cis- and trans-[PtCl(2)(NCCH(2)Ph)(2)] with a 5-fold excess of MeNH(2) and Me(2)NH in CH(2)Cl(2) at -10 degrees C affords in high yield the bis-amidine derivatives cis- and trans-[PtCl(2){Z-N(H)=C(NHMe)CH(2)Ph}(2)] (1a, 2a) and cis- and trans-[PtCl(2){EN(H)=C(NMe(2))CH(2)Ph}(2)] (3a, 4a), respectively. The complexes were characterized by means of elemental analysis, multinuclear NMR and FT-IR techniques. The X-ray diffraction analysis was carried out for trans-[PtCl(2){Z-N(H)=C(NHMe)CH(2)Ph}(2)] (2a).Moreover, the in vitro cytotoxicity for the new derivatives was evaluated in a wide panel of human tumor cell lines. (c) 2008 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ica.2007.10.054