diethyl amino(adamant-1-yl)methanephosphonate oxalate | 104130-99-6

• 英文名称: diethyl amino(adamant-1-yl)methanephosphonate oxalate
• CAS: 104130-99-6
• 化学式: C₂H₂O₄*C₁₅H₂₈NO₃P
• 分子量: 391.401
• InChiKey: GADQHVSFLPSHCC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.96
• 重原子数：
  26.0
• 可旋转键数：
  7.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  128.31
• 氢给体数：
  3.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  N-Carbobenzoxy-L-alanin-kohlensaeureaethylesteranhydrid 、 diethyl amino(adamant-1-yl)methanephosphonate oxalate 在 三乙胺 作用下， 以 氯仿 为溶剂， 生成
  参考文献：
  名称：

  Antibacterial activity of phosphono dipeptides related to alafosfalin

  摘要：

  A series of dipeptides containing N-terminal alanine or leucine and a wide range of P-terminal racemic 1-amino-alkanephosphonates were prepared and tested in vitro for their ability to inhibit the growth of various bacterial species. The results demonstrate that peptides containing 4-amino-4-phosphonobutyric acid and 1-amino-1-methylethanephosphonic acid exhibit antibacterial activity comparable with that observed in the case of peptides containing P-terminal racemic 1-aminoethanephosphonic acid (analogue of alanine) used as a positive control.

  DOI：

  10.1021/jm00161a014