N,N'-3,7-diazabicyclo[3.3.1]nonane-dichloro-platinum(ii) dimethylformamide | 1582802-52-5

• 英文名称: N,N'-3,7-diazabicyclo[3.3.1]nonane-dichloro-platinum(ii) dimethylformamide
• 英文别名: (3,7-diazabicyclo[3.3.1]nonane)PtCl2*DMF
• CAS: 1582802-52-5
• 化学式: C₃H₇NO*C₇H₁₄Cl₂N₂Pt
• 分子量: 465.282
• InChiKey: GKVSVMLKJFFKSZ-GALBCHNISA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  3,7-diazabicyclo{3.3.1}nonane 、 1,5-hexadieneplatinum(II) dichloride 、 N,N-二甲基甲酰胺 反应 3.0h， 以87%的产率得到N,N'-3,7-diazabicyclo[3.3.1]nonane-dichloro-platinum(ii) dimethylformamide
  参考文献：
  名称：

  Bispidine Analogues of Cisplatin, Carboplatin, and Oxaliplatin. Synthesis, Structures, and Cytotoxicity

  摘要：

  Bispidine (3,7-diazabicyclo[3.3.1]nonane, C2H14N2) analogues of cisplatin, carboplatin, and oxaliplatin have been prepared. ((C714N2)-N-H)PtCl2 center dot DMF (1b), obtained from (1,5-hexadiene)PtCl2 and bispidine in DMF, is dimeric in the solid state. Dissolving 1b in hot N-methylformamide allows crystallization of the solvent-free polymeric (C2H14N2)PtCl2 (1a). Recrystallization of 1a,b from hot water yields the trihydrate (C2H14N2)PtCl2 center dot 3H(2)O (1c). Reaction of 1 with Ag-2(cbdca) (cbdca = 1,1-cyclobutanedicarboxylate) in water affords the pentahydrate (C2H14N2)Pt{C4H6(CO2)(2)}center dot 5H(2)O (2b), which loses water in vacuo to give (C2H14N2)Pt(C4H6(CO2)(2)) (2a). Reaction of 1 with AgNO3 in water, followed by addition of Na2C2O4, affords the water-free polymeric (C2H14N2)Pt(C2O4) (3). All complexes have been structurally characterized, revealing various patterns of N-H...Cl and N-H...O hydrogen bonds. In the hydrates 1c and 2b the complexes are embedded in intricate three-dimensional water networks. Complexes la, 2a, and 3 have been tested for their cytotoxicity against human cancer cell lines K562 (chronic myeloid leukemia), A2780 (ovarian cancer), and its platinum-resistant subline A2780 CisR and are compared to their parent analogues. The new complexes show significant cytotoxic activity along with a low platinum resistance factor.

  DOI：

  10.1021/ic402737f

文献信息

• [EN] NOVEL DIAZABICYCLOHYDROCARBON-PT COMPLEXES AND THE USE THEREOF AS PHARMACEUTICALS<br/>[FR] NOUVEAUX COMPLEXES DE DIAZABICYCLOHYDROCARBURE-PT ET LEUR UTILISATION EN TANT QUE PRODUITS PHARMACEUTIQUES
  申请人：STUDIENGESELLSCHAFT KOHLE MBH

  公开号：WO2015118134A1

  公开（公告）日：2015-08-13

  The present invention relates to platinum complexes with diazabicyclo- hydrocarbon compounds of the general formula (I), processes for preparing said complexes and the use thereof as pharmaceutically active compounds, in particular as cytostatic compounds.

  本发明涉及具有一般式（I）的二氮杂双环烃化合物的铂配合物，制备该配合物的方法以及将其用作药用活性化合物，特别是作为细胞毒性化合物的用途。