3-(hydrazineylidenemethyl)-7-methoxyquinoline-2-thiol | 1179529-79-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 3-(hydrazineylidenemethyl)-7-methoxyquinoline-2-thiol
• CAS: 1179529-79-3
• 化学式: C₁₁H₁₁N₃OS
• 分子量: 233.294
• InChiKey: NHDMMJHCVNRVRQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.82
• 重原子数：
  16.0
• 可旋转键数：
  2.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  60.5
• 氢给体数：
  2.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  7-methyl-2-phenyl-4H-benzo[d][1,3]oxazin-4-one 、 3-(hydrazineylidenemethyl)-7-methoxyquinoline-2-thiol 在 吡啶 作用下， 以 乙醇 为溶剂， 以68%的产率得到3-{[(2-mercapto-7-methoxyquinolin-3-yl)methylene]amino}-7-methyl-2-phenylquinazolin-4(3H)-one
  参考文献：
  名称：

  Synthesis of Quinoline-Based Thieno-Seleno-Phenylquinazolinones

  摘要：

  The synthesis of quinoline-substituted phenylquinazolinones containing sulfur and selenium is described. These molecules were isolated from a series of reactions of 2-phenyl-4H-3,1-benzoxazin-4-one with 2-chloro, 2-thieno, and 2-selenoquinoline-3-carbaldehyde hydrazones. The structure of the isolated compounds has been elucidated on the basis of IR, 1H NMR, mass spectral, and elemental analysis data.

  DOI：

  10.1080/10426500802176945
• 作为产物：
  描述：

  7-methoxy-3-formyl-2-mercaptoquinoline 在 一水合肼 作用下， 生成 3-(hydrazineylidenemethyl)-7-methoxyquinoline-2-thiol
  参考文献：
  名称：

  Synthesis of Quinoline-Based Thieno-Seleno-Phenylquinazolinones

  摘要：

  The synthesis of quinoline-substituted phenylquinazolinones containing sulfur and selenium is described. These molecules were isolated from a series of reactions of 2-phenyl-4H-3,1-benzoxazin-4-one with 2-chloro, 2-thieno, and 2-selenoquinoline-3-carbaldehyde hydrazones. The structure of the isolated compounds has been elucidated on the basis of IR, 1H NMR, mass spectral, and elemental analysis data.

  DOI：

  10.1080/10426500802176945