1,6-bis(chlorido[3-(oxo-κO)-2-methyl-4(1H)-pyridinonato-κO4](η6-biphenyl)ruthenium(II))hexane | 1164254-52-7

• 英文名称: 1,6-bis(chlorido[3-(oxo-κO)-2-methyl-4(1H)-pyridinonato-κO4](η6-biphenyl)ruthenium(II))hexane
• CAS: 1164254-52-7
• 化学式: C₄₂H₄₂Cl₂N₂O₄Ru₂
• 分子量: 911.852
• InChiKey: SASSQBVMRRMCFM-UHFFFAOYSA-J

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  [ruthenium(II)(η⁶-biphenyl)(chloride)(μ-chloride)]₂ 、 1,6-bis(3-hydroxy-2-methyl-4(1H)-pyridinon-1-yl)hexane 在 sodium methylate 作用下， 以 甲醇 为溶剂， 以46%的产率得到1,6-bis(chlorido[3-(oxo-κO)-2-methyl-4(1H)-pyridinonato-κO4](η6-biphenyl)ruthenium(II))hexane
  参考文献：
  名称：

  Influence of the Arene Ligand, the Number and Type of Metal Centers, and the Leaving Group on the in Vitro Antitumor Activity of Polynuclear Organometallic Compounds

  摘要：

  Dinuclear ruthenium complexes were shown to exhibit strong antiproliferative properties in human tumor cell lines. In order to extend the structure-activity relationships (SARs), a series of new Ru-II(arene)X complexes (X = Cl, Br, I) linked by pyridinone-based spacers were synthesized and assayed for their in vitro antineoplastic effect. The SARs were established in terms of the arene ligand. the leaving group (the halide ligand), and the nature and number of the metal centers. It was demonstrated that, besides the previously shown effect or the spacer length, the nature of the metal center has the biggest influence on the in vitro anticancer activity. The halide ligand had no effect on the cytotoxicity, due to rapid formation of the same aquation product for all evaluated compounds. Furthermore, nearly identical activity was observed when varying the arene ligand from p-cymene to biphenyl. However, the number of metal centers was found to be important, with the dinuclear compound being more active than the analogous mono- and trinuclear species.

  DOI：

  10.1021/om900715j