[(η5-C5H5)ruthenium(II)(η6-9H-fluoren-9-one)]PF6 | 1258298-59-7

• 英文名称: [(η5-C5H5)ruthenium(II)(η6-9H-fluoren-9-one)]PF6
• CAS: 1258298-59-7
• 化学式: C₁₈H₁₃ORu*F₆P
• 分子量: 491.335
• InChiKey: UMMKTSHORTXDQC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  cyclopentadienylruthenium(II) trisacetonitrile hexafluorophosphate 、 9-芴酮 以 二氯甲烷 为溶剂， 以80%的产率得到[(η5-C5H5)ruthenium(II)(η6-9H-fluoren-9-one)]PF6
  参考文献：
  名称：

  New ruthenium(II) mixed metallocene derived complexes: Synthesis, characterization by X-ray diffraction and evaluation on DNA interaction by atomic force microscopy

  摘要：

  A new family of Ru(II) mixed metallocene complexes of the type [Ru(eta(5)-C5H5)(eta(6)-arene)][PF6] has been synthesized and fully characterized by NMR and UV-Vis spectroscopy. X-ray analysis of single crystal was achieved for all the complexes and revealed the presence of two enantiomers expected for planar chirality originated by the eta(6) coordination of the arene prochiral ligands. Studies of interaction of the new complexes with pBR322 DNA by atomic force microscopy showed very strong and different types of interaction. Antiproliferative tests were examined on human leukemia cancer cells (HL-60) using the MTT assay, and the IC50 values revealed low antiproliferative activity compared to cisplatin. (c) 2010 Elsevier B. V. All rights reserved.

  DOI：

  10.1016/j.ica.2010.05.034