1-(6-Fluorobenzo[b]thiophen-5-yl)-2-(1-piperazinyl)ethanol | 179616-82-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻吩类
• 英文名称: 1-(6-Fluorobenzo[b]thiophen-5-yl)-2-(1-piperazinyl)ethanol
• 英文别名: 1-(6-Fluoro-1-benzothiophen-5-yl)-2-piperazin-1-ylethanol
• CAS: 179616-82-1
• 化学式: C₁₄H₁₇FN₂OS
• 分子量: 280.366
• InChiKey: QLQHKVFNZKEJRZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  63.7
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Agent for potentiating nerve growth factor activity containg 1,2-ethanediol derivate or salt thereof
  申请人：TOYAMA CHEMICAL CO., LTD.

  公开号：EP1223169A1

  公开（公告）日：2002-07-17

  A remedy for diseases caused by degeneration of central nervous system, comprising a 1,2-ethanediol derivative represented by the following general formula or its salt: wherein R1 represents a substituted or unsubstituted phenyl, naphthyl, indanyl, indenyl, tetrahydronaphthyl or heterocyclic group; R2 represents a hydrogen atom, a C1-6alkyl group or a hydroxyl-protecting group; R3 represents a hydrogen atom or a C1-6alkyl group; nR4's may be the same as or different from one another and each represents a hydrogen atom or a C1-6alkyl group; nR5's may be the same as or different from one another and each represents a hydrogen atom or a C1-6alkyl group; R6 represents a substituted or unsubstituted amino or nitrogen-containing heterocyclic group or an ammonio group; and n represents 0 or an integer of 1 to 6, provided that the following 1,2-ethanediol derivative represented by general formula or its salt: wherein nR1a'S may be the same as or different from one another and each represents a fluorine, chlorine, bromine or iodine atom, C1-6alkyl, C1-6alkoxy or phenyl group; R2a represents a hydrogen atom or a hydroxyl-protecting group; R6a represents a C1-6alkyl-substituted amino group or a pyrrolyl, pyrrolidinyl, piperidyl, piperazinyl, imidazolyl, pyrazolyl, pyridyl, tetrahydropyridyl, pyrimidinyl, morpholinyl, thiomorpholinyl, quinolyl, quinolidinyl, tetrahydroquinolinyl, tetrahydroisoquinolinyl, quinuclidinyl, thiazolyl, tetrazolyl, thiadiazolyl, pyrrolinyl, imidazolinyl, imidazolidinyl, pyrazolinyl, pyrazolidinyl, purinyl, indazolyl, furyl, thienyl, benzothienyl, pyranyl, isobenzofuranyl, oxazolyl, benzofuranyl, indolyl, benzimidazolyl, benzoxazolyl, benzothiazolyl, quinoxalyl, dihydroquinoxalinyl, 2,3-dihydrobenzothienyl, 2,3-dihydrobenzopyrrolyl, 2,3-dihydro-4H-1-thianaphthyl, 2,3-dihydrobenzofuranyl, benzo[b]dioxanyl, imidazo[2,3-a]pyridyl, benzo[b]piperazinyl, chromenyl, isothiazolyl, isoxazolyl, thiadiazolyl, oxadiazolyl, pyridazinyl, isoindolyl or isoquinolyl group; and n represents an integer of 1 to 5, is excluded.

  一种治疗由中枢神经系统退化引起的疾病的药物，包括以下一般公式或其盐所代表的1,2-乙二醇衍生物：其中R1代表取代或未取代的苯基、萘基、茚基、茚基、四氢萘基或杂环基团；R2代表氢原子、C1-6烷基或羟基保护基团；R3代表氢原子或C1-6烷基；nR4可能相同也可能不同，每个代表氢原子或C1-6烷基；nR5可能相同也可能不同，每个代表氢原子或C1-6烷基；R6代表取代或未取代的氨基或含氮杂环基团或铵基；n代表0或1至6的整数，条件是以下一般公式或其盐所代表的1,2-乙二醇衍生物：其中nR1a'可能相同也可能不同，每个代表氟、氯、溴或碘原子、C1-6烷基、C1-6烷氧基或苯基；R2a代表氢原子或羟基保护基团；R6a代表C1-6烷基取代的氨基团或吡咯基、吡咯啉基、哌啶基、哌嗪基、咪唑基、吡唑基、吡啶基、四氢吡啶基、嘧啶基、吗啉基、硫代嘧啶基、喹啉基、喹啉啉基、四氢喹啉基、四氢异喹啉基、喹啉基、噻唑基、四唑基、噻二唑基、吡咯啉基、咪唑啉基、吡唑啉基、吡咯啉基、吲唑基、呋喃基、噻吩基、苯并噻吩基、吡喃基、异苯并呋喃基、噁唑基、苯并呋喃基、吲哚基、苯并咪唑基、苯并噁唑基、苯并噻嗪基、喹喃基、异吲哚基或异喹啉基团；n代表1至5的整数，被排除。
• POTENTIATOR FOR NERVE GROWTH FACTOR ACTIVITY CONTAINING 1,2-ETHANEDIOL DERIVATIVE OR SALT THEREOF
  申请人：TOYAMA CHEMICAL CO., LTD.

  公开号：EP0790246A1

  公开（公告）日：1997-08-20

  A 1,2-ethanediol derivative represented by the general formula [I] or its salt: has a NGF activity-potentiating effect and is useful as a remedy for various diseases caused by degeneration of central nervous system or peripheral nervous system such as senile dementia of Alzheimer type, Huntington's chorea, various neuropathies, Riley-Day syndrome, traumatic nerve injury, amyotrophic lateral sclerosis (ALS) and the like.

  一种由通式[I]或其盐代表的 1,2-乙二醇衍生物： 具有促进 NGF 活性的作用，可用于治疗中枢神经系统或周围神经系统退化引起的各种疾病，如阿尔茨海默型老年痴呆症、亨廷顿舞蹈症、各种神经病、瑞利-戴伊综合征、创伤性神经损伤、肌萎缩性脊髓侧索硬化症（ALS）等。
• Agent for potentiating nerve growth factor activity containing 1,2-ethanediol derivative or salt thereof
  申请人：TOYAMA CHEMICAL CO., LTD.

  公开号：EP1020427B1

  公开（公告）日：2003-10-01
• US5807887A
  申请人：——

  公开号：US5807887A

  公开（公告）日：1998-09-15
• US5922721A
  申请人：——

  公开号：US5922721A

  公开（公告）日：1999-07-13