eubotriol triacetate | 65053-61-4

• 英文名称: eubotriol triacetate
• 英文别名: triacetyleubotriol；[(1R,2S,4S,5S,9R,10S,13R,15S)-2,15-diacetyloxy-5,9-dimethyl-14-methylidene-5-tetracyclo[11.2.1.01,10.04,9]hexadecanyl]methyl acetate
• CAS: 65053-61-4
• 化学式: C₂₆H₃₈O₆
• 分子量: 446.584
• InChiKey: XLCPMQOZTHJVDQ-NVCRTNROSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  32
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.81
• 拓扑面积：
  78.9
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  eubol 、 乙酸酐 在 吡啶 作用下， 生成 eubotriol triacetate
  参考文献：
  名称：

  Antioxidant and Anticholinesterase Activity Evaluation of ent-Kaurane Diterpenoids from Sideritis arguta

  摘要：

  The petroleum ether and acetone extracts of the aerial parts of Sideritis arguta afforded two new and six known diterpenoids with the ent-kaurane skeleton. The structures of the new diterpenoids were determined as ent-7 alpha,18-diacetoxy-16 beta-hydroxykaurane (diacetyidistanol) (1) and ent-7 alpha-acetoxy,15 alpha,18-dihydroxykaur-16-ene (15-epi-eubol) (2) by spectroscopic data interpretation. Antioxidant potential was investigated for the ent-kauranes and the plant extracts by three methods (beta-carotene bleaching, free-radical scavenging, and superoxide-anion scavenging activity). Acetylcholinesterase and butyrylcholinesterase inhibitory activity were also evaluated, and the ent-kauranes eubol (3), sideroxol (5), and 7-epi-candicandiol (6) exhibited moderate butyrylcholinesterase inhibitory activity.

  DOI：

  10.1021/np800671p