1-ethyl-[3-(1(3)H-imidazol-4-yl)-propyl]-thiourea | 33550-65-1

• 英文名称: 1-ethyl-[3-(1(3)H-imidazol-4-yl)-propyl]-thiourea
• 英文别名: 1-ethyl-3-[3-(1H-imidazol-5-yl)propyl]thiourea
• CAS: 33550-65-1
• 化学式: C₉H₁₆N₄S
• 分子量: 212.319
• InChiKey: INUMQGHTUJTDBB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  84.8
• 氢给体数：
  3
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  异硫氰酸乙酯 、 Homohistamine dihydrobromide 在 sodium ethanolate 作用下， 生成 1-ethyl-[3-(1(3)H-imidazol-4-yl)-propyl]-thiourea
  参考文献：
  名称：

  New Analogs of Burimamide as Potent and Selective Histamine H3 Receptor Antagonists: The Effect of Chain Length Variation of the Alkyl Spacer and Modifications of the N-Thiourea Substituent

  摘要：

  Burimamide was one of the first compounds reported to antagonize the activation of the histamine H-3 receptor by histamine. We have prepared a large series of burimamide analogs by variation of the alkyl spacer length of burimamide from two methylene groups to six methylene groups and also by replacement of the N-methyl group with other alkyl and aryl groups. All analogs are reversible, competitive H-3 antagonists as determined on the guinea pig intestine. Elongation of the alkyl chain from an ethylene chain to a hexylene chain results in an increase of the H-3 antagonistic activity. The H-3 selective pentylene and hexylene analogs of burimamide are about 10 times more potent than burimamide. The N-thiourea substituents, however, have no beneficial influence on the affinity.

  DOI：

  10.1021/jm00012a025