[Ti{MePhC(η⁵-C₅H₄)₂}Cl₂] | 1542672-63-8

• 英文名称: [Ti{MePhC(η⁵-C₅H₄)₂}Cl₂]
• CAS: 1542672-63-8
• 化学式: C₁₈H₁₆Cl₂Ti
• 分子量: 351.111
• InChiKey: WAFSGRCGFMXIHR-UHFFFAOYSA-L

反应信息

• 作为产物：
  描述：

  titanium(IV) chloride tetrahydrofuran 、 环戊二烯 、 苯乙酮 在 sodium hydroxide 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 以0.8 g的产率得到[Ti{MePhC(η⁵-C₅H₄)₂}Cl₂]
  参考文献：
  名称：

  Study of the anticancer properties of methyl- and phenyl-substituted carbon- and silicon-bridged ansa-titanocene complexes

  摘要：

  The previously known complexes [Ti{(Me2CMe2C)(eta(5)-C5H4)(2)}Cl-2] (1), [Ti{Me2C(eta(5)-C5H4)(2)}Cl-2] (2), [Ti {Me2Si(eta(5)-C5H4)(2)}Cl-2] (4), [Ti{MePhSi(eta(5)-C5H4)(2)}Cl-2] (5) and [Ti{MePhSi(eta(5)-C5Me4)(2)}Cl-2] (6) have been prepared following reported procedures. The novel complex [Ti{MePhC(eta(5)-C5H4)(2)}Cl-2] (3) has been prepared and characterized. The cytotoxic activity of 1-6 has been tested after 72 h on melanoma A375 and B16, prostate cancer DU145 and LNCaP and colon cancer HCT116, SW620 and CT26CL25 cell lines observing a high cytotoxic activity of complexes 1 and 6 compared to the reference compound ([Ti(eta(5)-C5H5)(2)}Cl-2]). 1 and 6 have also been tested against primary normal mouse keratinocytes and lung fibroblasts. While viability of both type of primary cells was significantly less affected by 1 in comparison to the reference compound [Ti(eta(5)-C5H5)(2)Cl-2], compound 6 was completely nontoxic for nonmalignant cells, indicating a potential selectivity of this compound towards cancer cell lines. In addition CFSE staining, cell cycle analysis, AnnexinV-FITC/PI staining, detection of caspase activity and mitochondrial potential showed that 1 and 6 were acting through inhibition of proliferation and subsequent induction of mitochondrial dependent apoptosis in colon cancer cell lines, HCT116 and SW620, which express low sensitivity to cisplatin. Compound 6 was found to be the leading drug in this group since it shows the fastest and most selective anticancer profile. (C) 2013 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jorganchem.2013.07.059