[(η⁵-C₅Me₅)Ru(1,10-phenanthroline)(PPh₃)][PF₆] | 529499-24-9

• 英文名称: [(η⁵-C₅Me₅)Ru(1,10-phenanthroline)(PPh₃)][PF₆]
• 英文别名: [(η5-pentamethylcyclopentadienyl)(triphenylphosphine)(1,10-phenanthroline)ruthenium(II)] hexafluorophosphate
• CAS: 529499-24-9
• 化学式: C₄₀H₃₈N₂PRu*F₆P
• 分子量: 823.763
• InChiKey: OQLAQDSGDSTBPJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  1,10-菲罗啉 、 [(η5-pentamethylcyclopentadienyl)(triphenylphosphine)(acetonitrile)ruthenium(II)] hexafluorophosphate 以 二氯甲烷 、 苯 为溶剂， 以78%的产率得到[(η⁵-C₅Me₅)Ru(1,10-phenanthroline)(PPh₃)][PF₆]
  参考文献：
  名称：

  Synthesis and characterization of [(Cp*)Ru(PPh3)(N-base)]X and [(η5-C9H7)Ru(PPh3)(N-base)]X complexes: crystal and molecular structure of the complex [(η5-C9H7)Ru(PPh3)(phen)]PF6

  摘要：

  The reactions of [(eta(5)-Cp*)Ru(PPh3)(2)(CH3CN)]X (1) and [(eta(5)-indenyl)Ru(PPh3)(2)(CH3CN)]X (2) (eta(5)-CP* = eta(5)-C5Me5; eta(5)-indenyl = eta(5) -C9H7; X = BF4 or PF6) with 2,2'-bipyridine (bipy.) and 1,10-phenanthroline (phen.) in benzene or toluene yielded complexes of the type [(eta(5)-Cp*)Ru(PPh3)(L-2)]X where L-2 = bipy, X = BF4 (3) and L-2 = phen, X = PF6 (4); [(eta(5)-indenyl)Ru(PPh3)(2)(L-2)]X where L2 = bipy, X = PF6 (5) and L2 = phen, X = PF6 (6). Complex 6 has been established by single crystal X-ray diffraction analysis. Complex 6 crystallizes in the monoclinic space group P 21/c, with a = 14.6020 (12), b = 12.7100 (17) and c = 18.981 (2) Angstrom, beta = 98.982 (9)degrees, V = 3479.5 (7) Angstrom(3) and Z = 4. These complexes can also be prepared from reactions Of [(eta(5)- Cp*)Ru(PPh3)(2)Cl] (7) and [(eta(5)-indenyl)Ru(PPh3)(2)Cl] (8) with the corresponding ligands in the presence of NH4PF6 or NH4BF4 in toluene. All the complexes were characterized by spectral and analytical data. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0277-5387(02)01335-9

文献信息

• Half-Sandwich Cyclopentadienylruthenium(II) Complexes: A New Antimalarial Chemotype
  作者：Sofia A. Milheiro、Joana Gonçalves、Ricardo M. R. M. Lopes、Margarida Madureira、Lis Lobo、Andreia Lopes、Fátima Nogueira、Diana Fontinha、Miguel Prudêncio、M. Fátima M. Piedade、Sandra N. Pinto、Pedro R. Florindo、Rui Moreira

  DOI：10.1021/acs.inorgchem.0c01795

  日期：2020.9.8

  absorption in infected erythrocytes and nuclear accumulation of both compounds. The lead compound Ru2 impaired asexual parasite differentiation, exhibiting fast parasiticidal activity against both ring and trophozoite stages of a synchronized culture of the P. falciparum 3D7 strain. These results point to cyclopentadienylruthenium(II) complexes as a highly promising chemotype for the development of dual-stage

  通式的“半三明治” cyclopentadienylruthenium一小库（II）化合物[（η 5 -C 5 - [R 5）的Ru（PPH 3）（NN）] [PF 6 ]，支架从工具箱迄今不存在的筛选抗疟原虫的抗CQ敏感3D7-GFP的血液阶段，抗CQ的Dd2和抗青蒿素的IPC5202恶性疟原虫菌株的活性以及伯氏疟原虫的肝阶段的活性。表现最佳的化合物具有两位数的活性，单位纳米纳摩尔IC 50血期疟原虫的抗疟疾价值，肝期寄生虫的纳摩尔活性以及对HepG2和Huh7哺乳动物细胞的残留细胞毒性。通过共聚焦荧光显微镜研究了附有7-硝基苯并恶二唑的荧光化合物Ru4和Ru5的寄生吸收/分布，揭示了被感染红细胞中的寄生虫选择性吸收和这两种化合物的核积累。铅化合物Ru2损害了无性寄生虫的分化，对恶性疟原虫同步培养的环和滋养体阶段均表现出快速的杀寄生虫活性。3D7株。这些结果表明，环戊二烯基钌（II）配合