(2-ClHgC6H4)Ph2P=N(t)Bu | 1180491-92-2

• 英文名称: (2-ClHgC6H4)Ph2P=N(t)Bu
• CAS: 1180491-92-2
• 化学式: C₂₂H₂₃ClHgNP
• 分子量: 568.448
• InChiKey: NPKFQLBIQWZLDT-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  (2-ClHgC6H4)Ph2P=N(t)Bu 在 (CH₃)3N 作用下， 以 甲醇 、 乙腈 为溶剂， 生成
  参考文献：
  名称：

  Synthesis and reactivity of gold(III) complexes containing cycloaurated iminophosphorane ligands

  摘要：

  Transmetallation reactions of ortho-mercurated iminophosphoranes (2-ClHgC6H4)Ph2P=NR with [AuCl4] gives new cycloaurated iminophosphorane complexes of gold(III) (2-Cl2AuC6H4)Ph2P=NR [R = (R, S)- or (S)-CHMePh, p-C6H4F, Bu-t], characterised by NMR and IR spectroscopies, ESI mass spectrometry and an X-ray structure determination on the chiral derivative R = (S)-CHMePh. The chloride ligands of these complexes can be readily replaced by the chelating ligands thiosalicylate and catecholate; the resulting derivatives show markedly higher anti-tumour activity versus P388 murine leukaemia cells compared to the parent chloride complexes. Reaction of (2-Cl2AuC6H4)Ph2P=NPh with PPh3 results in displacement of a chloride ligand giving the cationic complex [(2-Cl(PPh3)AuC6H4)Ph2P=NPh](+), indicating that the P=N donor is strongly bonded to the gold centre. (C) 2009 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ica.2009.04.024
• 作为产物：
  描述：

  triphenylphosphine-N-tertbutylimine 、 mercury(II) diacetate 、 lithium chloride 以 四氢呋喃 为溶剂， 以25%的产率得到(2-ClHgC6H4)Ph2P=N(t)Bu
  参考文献：
  名称：

  Synthesis and reactivity of gold(III) complexes containing cycloaurated iminophosphorane ligands

  摘要：

  Transmetallation reactions of ortho-mercurated iminophosphoranes (2-ClHgC6H4)Ph2P=NR with [AuCl4] gives new cycloaurated iminophosphorane complexes of gold(III) (2-Cl2AuC6H4)Ph2P=NR [R = (R, S)- or (S)-CHMePh, p-C6H4F, Bu-t], characterised by NMR and IR spectroscopies, ESI mass spectrometry and an X-ray structure determination on the chiral derivative R = (S)-CHMePh. The chloride ligands of these complexes can be readily replaced by the chelating ligands thiosalicylate and catecholate; the resulting derivatives show markedly higher anti-tumour activity versus P388 murine leukaemia cells compared to the parent chloride complexes. Reaction of (2-Cl2AuC6H4)Ph2P=NPh with PPh3 results in displacement of a chloride ligand giving the cationic complex [(2-Cl(PPh3)AuC6H4)Ph2P=NPh](+), indicating that the P=N donor is strongly bonded to the gold centre. (C) 2009 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ica.2009.04.024