(chlorido)(η²-cis-cyclooctene)(2-((decylimino)methyl)phenolato-κ²-N,O)platinum(II) | 1609159-76-3

• 英文名称: (chlorido)(η²-cis-cyclooctene)(2-((decylimino)methyl)phenolato-κ²-N,O)platinum(II)
• CAS: 1609159-76-3
• 化学式: C₂₅H₄₀ClNOPt
• 分子量: 601.132
• InChiKey: IPECWRUHPSNOCQ-MQBLCLHZSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  [PtCl2(cis-cyclooctene)]2 、 N-decylsalicylideneimine 在 正丁基锂 作用下， 以 正己烷 、 甲苯 为溶剂， 反应 21.0h， 以82%的产率得到(chlorido)(η²-cis-cyclooctene)(2-((decylimino)methyl)phenolato-κ²-N,O)platinum(II)
  参考文献：
  名称：

  Synthesis, characterization and anticancer properties of (salicylaldiminato)platinum(II) complexes

  摘要：

  Twelve new (salicylaldiminato) platinum(II) complexes have been prepared, characterized and examined for their in vitro cytotoxic properties against three human glioma cell lines LN18, LN405 and Hs683. Initial biotesting was done on platinum complexes 1-6, which display a wide range of physicochemical properties. Whereas introduction of aromatic rings in the complexes did not seem to have a significant impact on bioactivities, the length of the aliphatic group positively correlated with cytotoxicity in all cell lines. Complexes 2 and 3 were found to be particularly potent against LN18 cells as demonstrated by stronger cell growth inhibition when compared to cisplatin. These initial findings led us to develop an additional series of mono (salicylaldiminato) platinum(II) complexes 7-12, which were subjected to additional cytotoxicity studies but were less cytotoxic compared to the bis Schiff base complexes. These organometallic compounds could serve as interesting starting points for the development of novel therapeutic strategies to treat brain tumors. (C) 2014 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ica.2014.02.028