| 214911-90-7

• CAS: 214911-90-7
• 化学式: C₂₇H₂₈Cl₄IIrN₂O
• 分子量: 857.469
• InChiKey: KKNINEINAVQAFJ-ONEVTFJLSA-M

反应信息

• 作为产物：
  描述：

  bis(1,5-cyclooctadiene)diiridium(I) dichloride 、 N-methylmiconazolium iodide 在 sodium acetate 作用下， 以 四氢呋喃 为溶剂， 生成
  参考文献：
  名称：

  Azolidene Carbenes Derived from Biologically Relevant Molecules.¹ Synthesis and Characterization of Iridium Complexes of Imidazolidene Ligands Based upon the Antifungal Drugs Econazole and Miconazole

  摘要：

  The azole-based antifungal drugs econazole and miconazole are readily converted into imidazolidene carbenes, which are trapped by coordination to iridium(I). The resulting complexes are the first antifungal drug-metal conjugates incorporating an M-C sigma bond. This demonstration of the capacity of azole-containing bioactive molecules to form carbene ligands may open the door to the investigation of complexes derived from such species for a variety of biological and medicinal purposes.

  DOI：

  10.1021/ic9806277