[(η6-C6H5(CH2)2NHTf)RuCl2]2 | 1078722-22-1

• 英文名称: [(η6-C6H5(CH2)2NHTf)RuCl2]2
• 英文别名: [Ru(η⁶-1,1,1-trifluoro-N-phenethylmethanesulfonamide)Cl₂]₂
• CAS: 1078722-22-1
• 化学式: C₁₈H₂₀Cl₄F₆N₂O₄Ru₂S₂
• 分子量: 850.442
• InChiKey: DQJICNUBKPWIDM-UHFFFAOYSA-J

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
  None
• 氢给体数：
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• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  [(η6-C6H5(CH2)2NHTf)RuCl2]2 、 乙腈 以 乙腈 为溶剂， 生成 [η6:η1-C6H5(CH2)2NTf]RuCl(CH3CN)
  参考文献：
  名称：

  Well-Defined Triflylamide-Tethered Arene−Ru(Tsdpen) Complexes for Catalytic Asymmetric Hydrogenation of Ketones

  摘要：

  Well-defined triflylamide-tethered arene-Ru(Tsdpen) complexes have been developed as highly efficient catalysts for the asymmetric hydrogenation of ketones, in which the suitable carbon chain length of the tether is responsible for the activation of H, as well as the stereochemical outcome of the reaction. The asymmetric hydrogenation of aromatic ketones with the tethered complex with a C-4 side chain gave the corresponding secondary alcohols with 91-98% ee, while the shorter congeners with a C-2 or C-3 side chain provided unsatisfactory results in tems of reactivity and selectivity.

  DOI：

  10.1021/om800735z
• 作为产物：
  描述：

  水合三氯化钌 、 N-(2-(cyclohexa-1,4-dien-1-yl)ethyl)-1,1,1-trifluoromethanesulfonamide 以 not given 为溶剂， 生成 [(η6-C6H5(CH2)2NHTf)RuCl2]2
  参考文献：
  名称：

  Well-Defined Triflylamide-Tethered Arene−Ru(Tsdpen) Complexes for Catalytic Asymmetric Hydrogenation of Ketones

  摘要：

  Well-defined triflylamide-tethered arene-Ru(Tsdpen) complexes have been developed as highly efficient catalysts for the asymmetric hydrogenation of ketones, in which the suitable carbon chain length of the tether is responsible for the activation of H, as well as the stereochemical outcome of the reaction. The asymmetric hydrogenation of aromatic ketones with the tethered complex with a C-4 side chain gave the corresponding secondary alcohols with 91-98% ee, while the shorter congeners with a C-2 or C-3 side chain provided unsatisfactory results in tems of reactivity and selectivity.

  DOI：

  10.1021/om800735z

文献信息

• The Application of Reversible Intramolecular Sulfonamide Ligation to Modulate Reactivity in Organometallic Ruthenium(II) Diamine Complexes
  作者：Samuel A. Kemp、Timothy J. Prior、Huguette Savoie、Ross W. Boyle、Benjamin S. Murray

  DOI：10.3390/molecules25020244

  日期：——

  variation of the sulfonamide R group and the length of the tether linking it to the arene ligand the acidity of the sulfonamide NH group, and hence the pH-region over which regulation of metal coordination occurs, can be modulated. Intramolecular sulfonamide ligation controlled the reactivity of complex 4 within the physiologically relevant pH-region, rendering it more reactive towards 5ʹ-GMP in mildly acidic

  生物大分子物质的金属化形成了许多金属药物抗癌活性的基础。这些化合物的一个主要限制是它们的反应性是不分青红皂白的，原则上可以发生在健康组织和癌组织中，可能导致体内副作用。在这里，我们提出了有机金属钌 (II) 乙二胺配合物中芳烃系磺酰胺官能团的 pH 依赖性分子内配位，作为控制中心金属原子配位环境的途径。通过改变磺酰胺 R 基团和将其连接到芳烃配体的系链长度，可以调节磺酰胺 NH 基团的酸度，从而调节金属配位调节发生的 pH 区域。分子内磺酰胺连接控制复合物 4 在生理相关 pH 区域内的反应性，使其在肿瘤组织典型的弱酸性 pH 条件下对 5ʹ-GMP 的反应性比健康组织典型的弱碱性 pH 条件更具反应性。然而，发现通过螯合物开环激活 4 相对于典型细胞培养测定的时间尺度是一个缓慢的过程，并且发现这一系列复合物的成员对 HT-29 细胞系没有细胞毒性。这些复合物为开发增强效力的类似物提供了基础，其中分子内磺酰胺连接以
• pH-Dependent Modulation of Reactivity in Ruthenium(II) Organometallics
  作者：Timothy J. Prior、Huguette Savoie、Ross W. Boyle、Benjamin S. Murray

  DOI：10.1021/acs.organomet.7b00868

  日期：2018.2.12

  The pH-dependent intramolecular chelation of a tethered sulfonamide ligand in ruthenium(II) arene complexes is demonstrated, a process shown to modulate metal-centered reactivity toward the model ligand guanosine 5′-monophosphate within the physiologically relevant pH region.

  证明了钌（II）芳烃配合物中束缚的磺酰胺配体的pH依赖性分子内螯合，该过程显示出在生理相关的pH范围内调节了以金属为中心的对模型配体鸟苷5'-单磷酸的反应性。