cis-PtCl2(4-pyridinehydroxamic acid)2*H2O | 959143-22-7

• 英文名称: cis-PtCl2(4-pyridinehydroxamic acid)2*H2O
• 英文别名: cis-[PtCl2(4-pyhaH)2]*H2O
• CAS: 959143-22-7
• 化学式: C₁₂H₁₂Cl₂N₄O₄Pt*H₂O
• 分子量: 560.253
• InChiKey: XRXYUUMRWZTNJI-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
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• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  K[Ru^III(ethylenediaminetetraacetate)Cl].2H₂O 、 cis-PtCl2(4-pyridinehydroxamic acid)2*H2O 以 水 为溶剂， 生成 K[Ru(II)(Hedta)(NO)Cl]*H2O
  参考文献：
  名称：

  Novel platinum pyridinehydroxamic acid complexes: Synthesis, characterisation, X-ray crystallographic study and nitric oxide related properties

  摘要：

  Herein, we describe the synthesis and characterisation of a novel class of Pt-II and Pt-IV pyridinehydroxamic acid (pyhaH) complexes of general formula cis-[(PtCl2)-Cl-II(x-pyhaH)(2)] and cis-[(PtCl4)-Cl-IV(x-pyhaH)(2)], respectively (where x = 3 or 4) in which the pyridinehydroxamic acid is coordinated to the platinum ion via the pyridine nitrogen only leaving the hydroxamic acid free to potentially release cytotoxic nitric oxide (NO). The crystal structure of the Pt-IV derivative, cis-[PtCl4(4-pyhaH)(2)]center dot 2CH(3)OH is reported. To establish the biological effect of the uncoordinated hydroxamic acid moiety in the Pt-II compounds synthesised, the corresponding pyridinecarboxylic acid (pycaH) complexes of general formula cis-[(PtCl2)-Cl-II(x-pycaH)(2)] (where x = 3 or 4) and the Nil pyridine (py) complex, cis-[(PtCl2)-Cl-II(py)(2)] were synthesised and served as reference standards. The NO-releasing properties of each of the Pt-II compounds, the pyhaH and the pycaH ligands were studied. The Pt-II pyridinehydroxamic acid derivatives were found to induce potent in vitro effects attributable to either NO-release from the hydroxamic acid moiety and/or stimulation of inducible nitric oxide synthase of endothelial cells. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.poly.2007.03.011
• 作为产物：
  描述：

  potassium tetrachloroplatinate(II) 、 水 、 N-羟基-(9ci)-4-吡啶甲亚胺酸 以 甲醇 、 水 为溶剂， 以70%的产率得到cis-PtCl2(4-pyridinehydroxamic acid)2*H2O
  参考文献：
  名称：

  Novel platinum pyridinehydroxamic acid complexes: Synthesis, characterisation, X-ray crystallographic study and nitric oxide related properties

  摘要：

  Herein, we describe the synthesis and characterisation of a novel class of Pt-II and Pt-IV pyridinehydroxamic acid (pyhaH) complexes of general formula cis-[(PtCl2)-Cl-II(x-pyhaH)(2)] and cis-[(PtCl4)-Cl-IV(x-pyhaH)(2)], respectively (where x = 3 or 4) in which the pyridinehydroxamic acid is coordinated to the platinum ion via the pyridine nitrogen only leaving the hydroxamic acid free to potentially release cytotoxic nitric oxide (NO). The crystal structure of the Pt-IV derivative, cis-[PtCl4(4-pyhaH)(2)]center dot 2CH(3)OH is reported. To establish the biological effect of the uncoordinated hydroxamic acid moiety in the Pt-II compounds synthesised, the corresponding pyridinecarboxylic acid (pycaH) complexes of general formula cis-[(PtCl2)-Cl-II(x-pycaH)(2)] (where x = 3 or 4) and the Nil pyridine (py) complex, cis-[(PtCl2)-Cl-II(py)(2)] were synthesised and served as reference standards. The NO-releasing properties of each of the Pt-II compounds, the pyhaH and the pycaH ligands were studied. The Pt-II pyridinehydroxamic acid derivatives were found to induce potent in vitro effects attributable to either NO-release from the hydroxamic acid moiety and/or stimulation of inducible nitric oxide synthase of endothelial cells. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.poly.2007.03.011