Cu(dthp)Cl₂ | 1417405-65-2

• 英文名称: Cu(dthp)Cl₂
• CAS: 1417405-65-2
• 化学式: C₁₁H₇Cl₂CuN₃S₂
• 分子量: 379.781
• InChiKey: WGKBSZDGDBJHGJ-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  copper(II) choride dihydrate 、 2,6-di(thiazol-2-yl)pyridine 以 甲醇 为溶剂， 反应 2.0h， 以68%的产率得到Cu(dthp)Cl₂
  参考文献：
  名称：

  Synthesis, crystal structure, DNA interaction and anticancer activity of tridentate copper(II) complexes

  摘要：

  Three new tridentate copper(II) complexes [Cu(dthp)Cl-2] (1) (dthp = 2,6-di(thiazol-2-yl)pyridine), [Cu(dmtp)Cl-2] (2) (dmtp = 2,6-di(5-methyl-4H-1,2,4-triazol-3-yl)pyridine) and [Cu(dtp)Cl-2] (3) (dtp = 2,6-di(4H-1,2,4-triazol-3-yl)pyridine) have been synthesized and characterized. Crystal structure of complex 1 shows that the complex existed as distorted square pyramid with five co-ordination sites occupied by the tridentate ligand and the two chlorine anions. Ethidium bromide displacement assay, viscosity measurements, circular dichroism studies and cyclic voltammetric experiments suggested that these complexes bound to DNA via an intercalative mode. Three Cu(II) complexes were found to efficiently cleave DNA in the presence of sodium ascorbate, and singlet oxygen (O-1(2)) and hydrogen peroxide were proved to contribute to the DNA cleavage process. They exhibited anticancer activity against HeLa, Hep-G2 and BEL-7402 cell lines. Nuclear chromatin cleavage has also been observed with AO/EB staining assay and the alkaline single-cell gel electrophoresis (comet assay). The results demonstrated that three Cu(II) complexes cause DNA damage that can induce the apoptosis of BEL-7402 cells. (C) 2012 Elsevier Inc. All rights reserved.

  DOI：

  10.1016/j.jinorgbio.2012.09.019