bis(cyclopentadienyl)vanadium(IV) (phenyl benzohydroxamato)trifluoromethanesulfonate | 208989-72-4

• 英文名称: bis(cyclopentadienyl)vanadium(IV) (phenyl benzohydroxamato)trifluoromethanesulfonate
• CAS: 208989-72-4
• 化学式: CF₃O₃S*C₂₃H₂₀NO₂V
• 分子量: 542.429
• InChiKey: GHGMPZFJPJCFPA-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  二氯化二茂钒 、 N-苯甲酰苯基羟胺 、 silver trifluoromethanesulfonate 以 乙醇 、 水 为溶剂， 以62%的产率得到bis(cyclopentadienyl)vanadium(IV) (phenyl benzohydroxamato)trifluoromethanesulfonate
  参考文献：
  名称：

  Interactions of Vanadocene(IV)-Chelated Complexes with Artificial Membranes

  摘要：

  The membrane interactions of five vanadocene(rv)-chelated complexes, which are very effective spermicidal agents, have been studied using zwitterionic and negative unilamellar liposomes. In permeability studies, bis(cyclopentadienyl)vanadium(TV) (2,2'-bipyridine)trifluoromethanesulfonate (1) and bis(cyclopentadienyl)vanadium(IV) (phenyl benzohydroxamato)trifluoromethanesulfonate (2) cause the release of about 35% and 20% encapsulated carboxyfluorescein, respectively, in both types of liposomes, whereas the congeneric vanadocene derivatives of diethyl dithiocarbamate (3), acetyl acetonate (4), and catecholate (5) have little or no effect on the permeability. Of the five compounds, only 4 and 1 initiate peroxidation of the lipids. None of the vanadocene-chelated complexes cause appreciable liposome aggregation, fusion, or changes in packing order of the liposomes as observed from UV/vis spectroscopy, fluorescence energy resonance transfer,and fluorescence polarization studies. The ability of the two vanadocene derivatives (1 and 2) to cause the liposomes to become permeable is therefore not related to the extent of peroxidation of the lipids or to complete disruption of the membrane. We propose that these vanadocene-chelated complexes have unique configurational preferences which alter the membrane by intercalation, creating "leaky patches" in the liposomal membrane.

  DOI：

  10.1021/jp9831637