3-(2,3-Dihydro-1-benzofuran-5-yl)-3-methylbutanenitrile | 465529-70-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 香豆素
• 英文名称: 3-(2,3-Dihydro-1-benzofuran-5-yl)-3-methylbutanenitrile
• CAS: 465529-70-8
• 化学式: C₁₃H₁₅NO
• 分子量: 201.268
• InChiKey: YECWNUSGBUMXEI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  33
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• N-phenpropylcuclopentyl-substituted glutaramide derivatives as inhibitors of neutral endopeptidase
  申请人：——

  公开号：US20030105132A1

  公开（公告）日：2003-06-05

  The invention relates to compounds of formula (I) for treating for example sexual dysfunction, wherein R 1 is optionally substituted C 1-6 alkyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, hydrogen, C 1-6 alkoxy, —NR 2 R 3 or —NR 4 SO 2 R 5 ; X is the linkage —(CH 2 ) n — or —(CH 2 ) q —O— (wherein Y is attached to the oxygen); wherein one or more hydrogen atoms in linkage X may be replaced independently by C 1-4 alkoxy; hydroxy; hydroxy(C 1-3 alkyl); C 3-7 cycloalkyl; carbocyclyl; heterocyclyl; or by C 1-4 alkyl optionally substituted by one or more fluoro or phenyl groups; n is 3, 4, 5, 6 or 7; and q is 2, 3, 4, 5 or 6; and Y is phenyl or pyridyl, each of which may be substituted; or two R 8 groups on adjacent carbon atoms together with the interconnecting carbon atoms may form a fused optionally substituted 5 - or 6 -membered carbocyclic or heterocyclyic ring. 1

  该发明涉及用于治疗性功能障碍的化合物(I)的公式，其中R1是可选择取代的C1-6烷基，可选择取代的碳环烷基，可选择取代的杂环烷基，氢，C1-6烷氧基，—NR2R3或—NR4SO2R5；X是连接基—(CH2)n—或—( )q—O—（其中Y连接到氧原子）；其中连接基X中的一个或多个氢原子可以独立地被C1-4烷氧基，羟基，羟基(C1-3烷基)，C3-7环烷基，碳环烷基，杂环烷基或可选择取代的一个或多个氟或苯基的C1-4烷基替代；n为3、4、5、6或7；q为2、3、4、5或6；Y为苯基或吡啶基，每个基都可以被取代；或相邻碳原子上的两个R8基连同相互连接的碳原子可以形成一个可选择取代的5-或6-成员碳环或杂环环。
• [EN] N-PHENPROPYLCYCLOPENTYL-SUBSTITUTED GLUTARAMIDE DERIVATIVES AS NEP INHIBITORS FOR FSAD<br/>[FR] DERIVES DE GUATARAMIDE N-PHENPROPYLCYCLOPENTYL-SUBSTITUES UTILISES COMME INHIBITEURS NEP POUR FSAD
  申请人：PFIZER LTD

  公开号：WO2002079143A1

  公开（公告）日：2002-10-10

  The invention relates to compounds of formula (I) for treating for example sexual dysfunction, wherein R1 is optionally substituted C¿1-6?alkyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, hydrogen, C1-6alkoxy, -NR2 R?3¿ or - NR4SO2R5; X is the linkage -(CH¿2?)n- or -(CH2)q-O- (wherein Y is attached to the oxygen); wherein one or more hydrogen atoms in linkage X may be replaced independently by C1-4alkoxy; hydroxy; hydroxy(C1-3alkyl); C3-7cycloalkyl; carbocyclyl; heterocyclyl; or by C1-4alkyl optionally substituted by one or more fluoro or phenyl groups; n is 3, 4, 5, 6, or 7; and q is 2, 3, 4, 5 or 6; and Y is phenyl or pyridyl, each of which may be substituted; or two R?8¿ groups on adjacent carbon atoms together with the interconnecting carbon atoms may form a fused optionally substituted 5- or 6-membered carbocyclic or heterocyclyic ring.

  本发明涉及化合物公式（I），用于治疗例如性功能障碍，其中R1是可选取代的C1-6烷基，可选取代的碳环基，可选取代的杂环基，氢，C1-6烷氧基，-NR2R3或-NR4SO2R5；X是连接基-(CH2)n-或-( )q-O-（其中Y连接到氧原子）；其中连接基X中的一个或多个氢原子可以独立地被C1-4烷氧基，羟基，羟基（C1-3烷基），C3-7环烷基，碳环基，杂环基或C1-4烷基替代，可选地被一个或多个氟或苯基取代；n为3、4、5、6或7；q为2、3、4、5或6；Y为苯基或吡啶基，每个基团都可以被取代；或相邻碳原子上的两个R8基团连同连接的碳原子可以形成螺合的、可选取代的5-或6元环碳环或杂环。
• N-phenpropylcyclopentyl-substituted glutaramide derivatives as inhibitors of neutral endopeptidase
  申请人：Pfizer Inc

  公开号：US20040106611A1

  公开（公告）日：2004-06-03

  The invention relates to compounds of formula (I) for treating for example sexual dysfunction, wherein R 1 is optionally substituted C 1-6 alkyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, hydrogen, C 1-6 alkoxy, —NR 2 R 3 or —NR 4 SO 2 R 5 ; X is the linkage —(CH 2 ) n — or —(CH 2 ) q —O— (wherein Y is attached to the oxygen); wherein one or more hydrogen atoms in linkage X may be replaced independently by C 1-4 alkoxy; hydroxy; hydroxy(C 1-3 alkyl); C 3-7 cycloalkyl; carbocyclyl; heterocyclyl; or by C 1-4 alkyl optionally substituted by one or more fluoro or phenyl groups; n is 3, 4, 5, 6 or 7; and q is 2, 3, 4, 5 or 6; and Y is phenyl or pyridyl, each of which may be substituted; or two R 8 groups on adjacent carbon atoms together with the interconnecting carbon atoms may form a fused optionally substituted 5- or 6-membered carbocyclic or heterocyclyic ring. 1

  本发明涉及式（I）的化合物，用于治疗性功能障碍，其中R1是可选取代的C1-6烷基，可选取代的碳环烷基，可选取代的杂环烷基，氢，C1-6烷氧基，-NR2R3或-NR4SO2R5; X是连接-（CH2）n-或-（ ）q-O-的链（其中Y连接到氧）;其中链X中的一个或多个氢原子可以独立地被C1-4烷氧基，羟基，羟基（C1-3烷基），C3-7环烷基，碳环烷基，杂环烷基或C1-4烷基取代，可选取代一个或多个氟或苯基; n为3、4、5、6或7; q为2、3、4、5或6; Y为苯基或吡啶基，每个基团均可取代; 或相邻碳原子上的两个R8基团与连接碳原子一起可以形成螺合的可选取代的5-或6-成员的碳环或杂环烷基环。
• N-PHENPROPYLCYCLOPENTYL-SUBSTITUTED GLUTARAMIDE DERIVATIVES AS NEP INHIBITORS FOR FSAD
  申请人：Pfizer Limited

  公开号：EP1373192A1

  公开（公告）日：2004-01-02
• US6660756B2
  申请人：——

  公开号：US6660756B2

  公开（公告）日：2003-12-09