| 1207748-59-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• CAS: 1207748-59-1
• 化学式: C₂₀H₁₄F₅NO₃
• 分子量: 411.328
• InChiKey: YUDFPUVUKIDRKZ-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  在 lithium hydroxide 作用下， 生成 5,8-difluoro-4-oxo-1-[3-(trifluoromethyl)benzyl]-1,4-dihydroquinoline-3-carboxylic acid
  参考文献：
  名称：

  Parallel synthesis of N-biaryl quinolone carboxylic acids as selective M1 positive allosteric modulators

  摘要：

  An iterative analog library synthesis approach was employed in the exploration of a quinolone carboxylic acid series of selective M-1 positive allosteric modulators, and strategies for improving potency and plasma free fraction were identified. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.11.100