1-(2,2,2-trifluoro-1-hydroxy-1-methylethyl)cyclopropanesulfonamide | 1397342-80-1

• 英文名称: 1-(2,2,2-trifluoro-1-hydroxy-1-methylethyl)cyclopropanesulfonamide
• 英文别名: 1-(1,1,1-trifluoro-2-hydroxypropan-2-yl)cyclopropane-1-sulfonamide
• CAS: 1397342-80-1
• 化学式: C₆H₁₀F₃NO₃S
• 分子量: 233.212
• InChiKey: NHFYXAPEFDIYOK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  88.8
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  1-(2,2,2-trifluoroacetyl)cyclopropanesulfonamide 、 甲基溴化镁 以 四氢呋喃 、 乙醚 为溶剂， 反应 4.0h， 以208 mg的产率得到1-(2,2,2-trifluoro-1-hydroxy-1-methylethyl)cyclopropanesulfonamide
  参考文献：
  名称：

  DI- AND TRI-SUBSTITUTED OXATHIAZINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, USE THEREOF AS MEDICINE AND DRUG CONTAINING SAID DERIVATIVES AND USE THEREOF

  摘要：

  该发明涉及式(I)的化合物及其生理兼容盐。所述化合物适用于治疗高血糖，例如。

  公开号：

  US20130345125A1

文献信息

• DI AND TRI - SUBSTITUTED OXATHIAZINE DERIVATIVES, METHOD FOR THE PRODUCTION, METHOD FOR THE PRODUCTION THEREOF, USE THEREOF AS MEDICINE AND DRUG CONTAINING SAID DERIVATIVES AND USE THEREOF
  申请人：Boehme Thomas

  公开号：US20130338150A1

  公开（公告）日：2013-12-19

  The invention relates to compounds of formula (I) and to the physiologically compatible salts thereof. Said compounds are suitable, for example, for treating hyperglycemia.

  该发明涉及公式（I）的化合物及其生理兼容盐。这些化合物适用于治疗高血糖，例如。
• TETRASUBSTITUTED OXATHIAZINE DERIVATIVES, METHOD FOR PRODUCING THEM, THEIR USE AS MEDICINE AND DRUG CONTAINING SAID DERIVATIVES AND THE USE THEREOF
  申请人：Boehme Thomas

  公开号：US20140024584A1

  公开（公告）日：2014-01-23

  The invention relates to the compounds of formula (I) and to the physiologically acceptable salts thereof. Said compounds are suitable e.g. for the treatment of hyperglycemia.

  该发明涉及式(I)的化合物以及其生理上可接受的盐。所述化合物适用于治疗高血糖等情况。
• Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof
  申请人：Boehme Thomas

  公开号：US08871758B2

  公开（公告）日：2014-10-28

  The invention relates to the compounds of formula (I) and to the physiologically acceptable salts thereof. Said compounds are suitable e.g. for the treatment of hyperglycemia.

  本发明涉及式(I)的化合物及其生理上可接受的盐。所述化合物适用于例如治疗高血糖等方面。
• Di and tri- substituted oxathiazine derivatives, method for the production, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
  申请人：Boehme Thomas

  公开号：US08710050B2

  公开（公告）日：2014-04-29

  The invention relates to compounds of formula (I) and to the physiologically compatible salts thereof. Said compounds are suitable, for example, for treating hyperglycemia.

  本发明涉及式(I)化合物及其生理相容盐。该化合物适用于治疗高血糖等疾病。
• Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
  申请人：Boehme Thomas

  公开号：US08828994B2

  公开（公告）日：2014-09-09

  The invention relates to compounds of formula (I) and to the physiologically compatible salts thereof. Said compounds are suitable, for example, for treating hyperglycemia.

  本发明涉及公式(I)的化合物及其生理相容盐。该化合物适用于治疗高血糖等疾病。