1-(2-fluorobenzoyl)-3-(4-ferrocenylphenyl)selenourea | 1445137-48-3

• 英文名称: 1-(2-fluorobenzoyl)-3-(4-ferrocenylphenyl)selenourea
• CAS: 1445137-48-3
• 化学式: C₂₄H₁₉FFeN₂OSe
• 分子量: 505.233
• InChiKey: QLNCAGDVMHGPPJ-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  4-ferrocenylaniline 、 以 丙酮 为溶剂， 反应 6.0h， 生成 1-(2-fluorobenzoyl)-3-(4-ferrocenylphenyl)selenourea
  参考文献：
  名称：

  Synthesis, Chemical Characterisation, and DNA Binding Studies of Ferrocene-Incorporated Selenoureas

  摘要：

  本文介绍了六种新的二茂铁硒脲的合成、化学特性（通过核磁共振和傅立叶变换红外光谱、原子吸收分光光度法、元素分析和单晶 X 射线衍射）、电化学和 DNA 结合研究（通过循环伏安法、粘度计和紫外可见光谱）。所有六种化合物都与 DNA 发生静电作用，这表现在药物-DNA 加合物的循环伏安法峰值电位相对于游离药物发生负移。药物与 DNA 的结合常数是通过在游离药物中加入 DNA 后峰值电流的下降计算得出的。我们还报告了合成化合物的结合位点大小和扩散系数。

  DOI：

  10.1071/ch12570

文献信息

• Ferrocene incorporated selenoureas as anticancer agents
  作者：Raja Azadar Hussain、Amin Badshah、John M. Pezzuto、Nadeem Ahmed、Tamara P. Kondratyuk、Eun-Jung Park

  DOI：10.1016/j.jphotobiol.2015.04.024

  日期：2015.7

  For a compound to be a best chemopreventive agent it should be a descent DNA binder and at the same time should be active against any of the three stages of carcinogenesis i.e. cancer initiation, cancer propagation and tumor growth. Most of the problems associated with chemotherapy can be overcome if the chemopreventive agent is active against all the three stages of cancer development. Cancer may be initiated by higher concentration of free radicals, inflammating agents and phase I enzymes (Cytochrome P450) in the body. Cancer propagation can be very efficiently controlled by inducing the phase II enzymes (glutathione S-transferases (GSTs), UDP-glucuronosyl transferases, and quinone reductases) in the body and cancer termination depends on the killing of the faulty cells i.e. cytotoxic actions. This article reports comprehensively the comparative DNA binding studies (with, cyclic voltammetry, UV-vis spectroscopy and viscometry), antioxidant activities (DPPH scavenging), anti-inflammatory activities (nitrite inhibition), phase I enzyme inhibition activities (aromatase inhibition), phase II enzyme induction studies (quinone reductase induction) and cytotoxic studies against neuroblastoma (MYCN2 and SK-N-SH), liver cancer (Hepa 1c1c7) and breast cancer (MCF-7) of seventeen ferrocene incorporated selenoureas. (C) 2015 Elsevier B.V. All rights reserved.