[Pb^II(2,4-diiodo-6-((pyridine-2-ylmethylamino)methyl)phenol)NO₃] | 1567836-13-8

• 英文名称: [Pb^II(2,4-diiodo-6-((pyridine-2-ylmethylamino)methyl)phenol)NO₃]
• 英文别名: [Pb^II(L^iodo)NO₃]
• CAS: 1567836-13-8
• 化学式: C₁₃H₁₁I₂N₃O₄Pb
• 分子量: 734.257
• InChiKey: XYTNHIPLZFAVJE-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  lead(II) nitrate 、 2,4-diiodo-6-((pyridine-2-ylmethylamino)methyl)phenol 在 三乙胺 作用下， 以 乙醇 为溶剂， 反应 24.0h， 以86%的产率得到[Pb^II(2,4-diiodo-6-((pyridine-2-ylmethylamino)methyl)phenol)NO₃]
  参考文献：
  名称：

  Inhibition of the 26S proteasome as a possible mechanism for toxicity of heavy metal species

  摘要：

  In this paper we report on the synthesis of five metal complexes coordinated to the [NN'O] ligand HL(iodo) (2,4-diiodo-6-((pyridine-2-ylmethylamino)methyl)phenol), namely [Al(III)(L(iodo))2]ClO4 (1), [Cd(II)(L(iodo))Cl]·H2O (2), [Hg(II)(L(iodo))2]·4DMSO (3), [Pb(II)(L(iodo))NO3] (4), and [Sn(IV)(L(iodo))Cl3] (5). Species 1-5 are thoroughly characterized by spectroscopic and spectrometric methods, as well as by elemental analysis. X-ray crystallography results for complex 3 indicate the presence of Hg(II) ion hexacoordinated to two facially oriented [NN'O] ligands, whereas for complex 5 an Sn(IV) ion chelates to one deprotonated ligand and three chlorido coligands. The toxicity of species 1-5 is tested against transformed human prostate epithelial cells CRL2221 and we observe that the five complexes demonstrate high levels of cell growth inhibition in a dose-dependent manner. In order to evaluate the relationship between these species and the proteasome, we test 1-5 against purified 20S, CRL2221 cell extracts, and intact cells, followed by the measurement of the percent chymotrypsin-like activity inhibition levels. Results suggest a good correlation between the toxicity of [Hg(II)(L(iodo))2]·4DMSO (3) and proteasome inhibition.

  DOI：

  10.1016/j.jinorgbio.2013.12.012