dichloridobis(dimethylsulphoxide)gold(III) chloride | 1421617-61-9

• 英文名称: dichloridobis(dimethylsulphoxide)gold(III) chloride
• CAS: 1421617-61-9
• 化学式: C₄H₁₂AuCl₂O₂S₂*Cl
• 分子量: 459.596
• InChiKey: YKZMVSZWFFZBDF-UHFFFAOYSA-K

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  potassium tetrachloroaurate(III) 、 二甲基亚砜 在 盐酸 、 sodium hydroxide 作用下， 以 水 、 二甲基亚砜 为溶剂， 反应 5.0h， 生成 dichloridobis(dimethylsulphoxide)gold(III) chloride
  参考文献：
  名称：

  Effects of aurothiomalate and gold(III) complexes on spontaneous motility of isolated human oviduct

  摘要：

  Organic gold complexes have different biological activity, depending on their potential for interactions with key functional molecules.The aim of this study was to investigate potential of several newly synthesized organic gold complexes to influence spontaneous motility of the Fallopian tubes.The effects of [Au(bipy)Cl-2](+) (dichloride(2,2'-bipyridyl)aurate(III)-ion), aurothiomalate, [Au(DMSO)(2)Cl-2]Cl and DMSO on spontaneous motility of Fallopian tubes were tested on the isolated tube segments in vitro. Aurothiomalate (from 2.9 x 10(-9) to 4.9 x 10(-4) M/l), [Au(bipy)Cl-2]Cl (from 3.3 x 10(-9) to 4.2 x 10(-5) M/l) and DMSO (from 1.9 x 10(-8) to 1.0 x 10(-5) M/l) did not affect spontaneous contractions of the isolated Fallopian tube ampulla, while [Au(DMSO)(2)Cl-2]Cl (from 2.9 x 10(-9) to 4.2 x 10(-5) M/l) showed concentration-dependent increase (stimulation) of spontaneous contractions of the isolated Fallopian tube isthmus, and remained without effect on the isolated ampulla.The drugs designed as organic gold complexes with weaker bonds between the gold itself and organic part of a molecule could adversely affect motility of the Fallopian tubes, and theoretically fertility of women taking such drugs in their reproductive age.

  DOI：

  10.1007/s10534-012-9558-2