2,2,4,4,6,6-hexaethyl-8-trichloromethyl-[1,3,5,7,2,4,6]tetraoxatrisilocane | 17962-14-0

• 英文名称: 2,2,4,4,6,6-hexaethyl-8-trichloromethyl-[1,3,5,7,2,4,6]tetraoxatrisilocane
• 英文别名: 2,2,4,4,6,6-Hexaaethyl-8-trichlormethyl-[1,3,5,7,2,4,6]tetraoxatrisilocan
• CAS: 17962-14-0
• 化学式: C₁₄H₃₁Cl₃O₄Si₃
• 分子量: 454.013
• InChiKey: CFHBLBOGMAAOGY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.21
• 重原子数：
  24.0
• 可旋转键数：
  6.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  36.92
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  水合氯醛 、 二氯二乙基硅烷 在 吡啶 作用下， 生成 2,2,4,4,6,6-hexaethyl-8-trichloromethyl-[1,3,5,7,2,4,6]tetraoxatrisilocane
  参考文献：
  名称：

  观察条件对根尖周炎放射学诊断的影响

  摘要：

  Objectives To determine the effect of viewing conditions upon diagnosis of early periapical inflammatory pathosis on intra-oral radiographs, and to examine the effect of observer experience upon diagnostic performance in this task.Methods 50 observers examined 18 periapical radiographs using three different viewing conditions (room lighting; viewing box; viewing box with x2 magnification and masking). Their diagnoses were compared with an 'expert' diagnosis provided by repeated viewings of the films by two dental radiologists. Sensitivities and specificities were determined.Results When 'ideal' viewing conditions were used, optimal sensitivity (78%) and specificity (78%) were obtained. Use of a viewing box was associated with significantly higher specificity than the use of room lighting (P = 0.0016). Use of masking and x2 magnification was associated with significantly higher sensitivity than a viewing box alone (P = 0.004). There were few significant differences in diagnostic performance between observers, but qualified dental staff had significantly higher specificities than 4th year (P = 0.01) and 5th year (P = 0.01) students when a viewing box was used alone.Conclusions This study on early periapical inflammatory pathosis gives support to guidelines which recommend the use of a viewing box, x2 magnification and masking for interpreting intra-oral radiographs. It also suggests that observer experience may influence interpretation of early periapical pathosis.

  DOI：

  10.1038/sj.bdj.4800596a