Zn{(η5-C5H5)Fe(η5-C5H4)C(H)NNC(S)NHC6H5}2*H2O | 1262147-53-4

• 英文名称: Zn{(η5-C5H5)Fe(η5-C5H4)C(H)NNC(S)NHC6H5}2*H2O
• 英文别名: bis(ferrocenecarbaldehyde 4-phenylthiosemicarbazonato-κ²N¹,S)zinc hydrate；Zn{(η⁵-C₅H₅)Fe(η⁵-C₅H₄)C(H)NNC(S)NHC₆H₅}₂*H₂O
• CAS: 1262147-53-4
• 化学式: C₃₆H₃₂Fe₂N₆S₂Zn*H₂O
• 分子量: 807.922
• InChiKey: WXNQJERHKXPBND-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  ferrocenecarboxaldehyde-4(N)-phenylthiosemicarbazone 、 zinc(II) acetate dihydrate 在 potassium hydroxide 作用下， 以 甲醇 为溶剂， 反应 4.0h， 以77%的产率得到Zn{(η5-C5H5)Fe(η5-C5H4)C(H)NNC(S)NHC6H5}2*H2O
  参考文献：
  名称：

  Zn(II)ferrocenylthiosemicarbazones: DNA Binding and Nuclease Activity

  摘要：

  A series of Zn(II) ferrocenylthiosemicarbazones complexes derived from thiosemicarbazide and 4-methyl-, 4-ethyl-, and 4-phenyl-3-thiosemicarbazide were evaluated for their DNA binding propensity and chemical nuclease activity. The equilibrium binding constants, K b, of the complexes for binding with calf thymus DNA (CT DNA) were in the range of 0.68 x 103 to 2.8 x 104 M-1. The complexes do not intercalate into the nucleobases of CT DNA, as evident from viscosity measurements. They exhibit efficient nuclease activity in the absence of an activating agent and cleave supercoiled DNA into nicked and linear circular forms of DNA at very low concentrations.

  DOI：

  10.1080/15533174.2012.680138