Zn2(μ-CH3COO)(CH3COO)2(H2O)(2-((diethylamino)methyl)-6-((dimethylamino)methyl-4-methyl phenol(1-)) | 1313876-61-7

• 英文名称: Zn2(μ-CH3COO)(CH3COO)2(H2O)(2-((diethylamino)methyl)-6-((dimethylamino)methyl-4-methyl phenol(1-))
• CAS: 1313876-61-7
• 化学式: C₂₁H₃₆N₂O₈Zn₂
• 分子量: 575.305
• InChiKey: QYFLZEIWCXPIDN-UHFFFAOYSA-J

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  2-((diethylamino)methyl)-6-((dimethylamino)methyl)-4-methyl phenol 、 zinc(II) acetate dihydrate 在 NaH 作用下， 以 正己烷 、 二氯甲烷 为溶剂， 以64%的产率得到Zn2(μ-CH3COO)(CH3COO)2(H2O)(2-((diethylamino)methyl)-6-((dimethylamino)methyl-4-methyl phenol(1-))
  参考文献：
  名称：

  Metallo-β-lactamase and phosphotriesterase activities of some zinc(II) complexes

  摘要：

  Metallo-beta-lactamases (m beta l) and phosphotriesterase (PTE) are zinc(II) enzymes, which hydrolyze the beta-lactam antibiotics and toxic organophosphotriesters, respectively. In the present work, we have synthesized a few asymmetric phenolate-based ligands by sequential Mannich reaction and their corresponding zinc(II) complexes. These zinc(II) complexes were studied for their m beta l and PTE activities. It is shown that the zinc(II) complexes can hydrolyze oxacillin, the beta-lactam antibiotic, at much higher rates as compared to the hydrolysis of p-nitrophenyl diphenylphosphate (PNPDPP), the phosphotriester. Among the complexes studied, the binuclear asymmetric complex 1 having a water molecule coordinated to one of the zinc(II) ions exhibits much better mbl activity than the mononuclear complexes. However, the mononuclear zinc(II) complexes having labile chloride ions exhibit significant PTE activity, which can be ascribed to the replacement of chloride ions by hydroxide ions during hydrolysis reactions. (C) 2011 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ica.2011.03.064