[2,5-Ph2-3,4-Tol2(η4-C4CO)](CO)2Ru(4-(N-benzylamino)aniline) | 869110-13-4

• 英文名称: [2,5-Ph2-3,4-Tol2(η4-C4CO)](CO)2Ru(4-(N-benzylamino)aniline)
• 英文别名: [2,5-Ph2-3,4-Tol2-(η4-C4CO)]Ru(CO)2[NH2C6H4NHCH2C6H5]；[2,5-Ph2-3,4-Tol2-(η4-C4CO)]Ru(CO)2[NH(CH2Ph)(C6H4NH2)]
• CAS: 869110-13-4；869110-14-5
• 化学式: C₄₆H₃₈N₂O₃Ru
• 分子量: 767.889
• InChiKey: KLYAJFMRIAHFDL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  [[2,5-Ph2-3,4-Tol2-(η4-C4CO)]Ru(CO)2]2 、 N1-苄基苯-1,4-二胺 以 二氯甲烷-D2 为溶剂， 以84%的产率得到[2,5-Ph2-3,4-Tol2(η4-C4CO)](CO)2Ru(4-(N-benzylamino)aniline)
  参考文献：
  名称：

  Reduction of Imines by Hydroxycyclopentadienyl Ruthenium Hydride:  Intramolecular Trapping Evidence for Hydride and Proton Transfer Outside the Coordination Sphere of the Metal

  摘要：

  Reduction of imines by [2,5-Ph-2-3,4-Tol(2)(eta(5)-C4COH)]Ru(CO)H-2 (2) produces kinetically stable ruthenium amine complexes. Reduction of an imine by 2 in the presence of an external amine trap gives only the complex of the newly generated amine. Reaction of 2 with H2N-p-C6H4N=CHPh (11), which contains an intramolecular amine trap, gave a 1:1 mixture of [2,5-Ph-2-3,4-Tol(2)(eta(4)-C4CO)](CO)(2)RuNH(CH2Ph)(C6H4-p-NH2) (8), formed by coordination of the newly generated amine to the ruthenium center, and [2,5-Ph-2-3,4-Tol(2)(eta(4)-C4CO)](CO)(2)RuNH2C6H4-p-NHCH2Ph (9), formed by coordination of the amine already present in the substrate. These results require transfer of hydrogen to the imine outside the coordination sphere of the metal to give a coordinatively unsaturated intermediate that can be trapped inside the initial solvent cage. Amine diffusion from the solvent cage must be much slower than coordination to the metal center. Mechanisms requiring prior coordination of the substrate to ruthenium would have led only to 8 and can be eliminated.

  DOI：

  10.1021/ja053956o

文献信息

• Isomerization and Deuterium Scrambling Evidence for a Change in the Rate-Limiting Step during Imine Hydrogenation by Shvo's Hydroxycyclopentadienyl Ruthenium Hydride
  作者：Charles P. Casey、Jeffrey B. Johnson

  DOI：10.1021/ja044450t

  日期：2005.2.1

  mechanism analogous to that proposed for aldehyde and ketone reduction. Reduction of electron-rich N-alkyl-substituted imine, N-isopropyl-(4-methyl)benzilidene amine (9), was accompanied by facile imine isomerization and scrambling of deuterium labels from reduction with 5-RuDOH into the N-alkyl substituent of both the amine complex and into the recovered imine. Inverse equilibrium isotope effects were

  羟基环戊二烯基氢化钌 5 可在室温以下有效还原亚胺。氮上更好的供体取代基导致更快的速率和速率决定步骤从氢转移到胺配位的转变。在 11 摄氏度时减少缺电子 N-亚苄基五氟苯胺 (8) 导致游离胺和 k(OH)/k(OD) = 1.61 +/- 0.08 的动力学同位素效应，k(RuH)/k(RuD) = 2.05 +/- 0.08 和 k(RuHOH)/k(RuDOD) = 3.32 +/- 0.14，表明限速协同氢转移，类似于醛和酮还原提出的机制。还原富电子的 N-烷基取代亚胺、N-异丙基-(4-甲基)联苯胺(9)、伴随着容易的亚胺异构化和氘标记从 5-RuDOH 还原到胺复合物的 N-烷基取代基和回收的亚胺中的混乱。在 -48 摄氏度的 N-亚苄基-叔丁胺 (11) 还原中观察到逆平衡同位素效应 (k(OH)/k(OD) = 0.89 +/- 0.06, k(RuH)/k(RuD) ) =
• Intramolecular Trapping of an Intermediate in the Reduction of Imines by a Hydroxycyclopentadienyl Ruthenium Hydride:  Support for a Concerted Outer Sphere Mechanism
  作者：Charles P. Casey、Timothy B. Clark、Ilia A. Guzei

  DOI：10.1021/ja073370x

  日期：2007.9.1

  Reduction of imines by [2,5-ph(2)-3,4-Tol(2)(eta(5)-C4COH)]Ru(CO)(2)H (1) produces kinetically stable ruthenium amine complexes. Reduction of an imine possessing an intramolecular amine was studied to distinguish between inner sphere and outer sphere mechanisms. 1,4-(BnNH)-N-15(c-C6H10)=NBn (12) was reduced by 1 in toluene-d(8) to give 85% of [2,5-Ph-2-3,4-Tol(2) (eta(4)-C4CO)](CO)(2)RuNHBn(c-C6H10)(NHBn)-N-15 (16-RuN,N-15), resulting from coordination of the newly formed amine to the ruthenium center, and 15% of trapping product [2,5-Ph-2-3,4-Tol(2) (eta(4)-C4CO)](CO)(2)(RuNHBn)-N-15(c-C6H10)NHBn (16-(RuN)-N-15,N), resulting from coordination of the intramolecular trapping amine. These results provide support for an outer sphere transfer of hydrogen to the imine to generate a coordinatively unsaturated intermediate, which can be trapped by the intramolecular amine. An opposing mechanism, requiring coordination of the imine nitrogen to ruthenium prior to hydrogen transfer, cannot readily explain the observation of the trapping product 16-(RuN)-N-15,N.