2-Amino-5-(4-hexyloxyphenyl)-1,3,4-oxadiazol | 92327-34-9

• 英文名称: 2-Amino-5-(4-hexyloxyphenyl)-1,3,4-oxadiazol
• 英文别名: 5-(4-hexyloxy-phenyl)-[1,3,4]oxadiazol-2-ylamine；5-(4-Hexoxyphenyl)-1,3,4-oxadiazol-2-amine
• CAS: 92327-34-9
• 化学式: C₁₄H₁₉N₃O₂
• 分子量: 261.324
• InChiKey: OBULXSZAUDILDA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  19
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  74.2
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  1-<4-Hexyloxy-benzoyl>-S-methyl-isothiosemicarbazid 生成 2-Amino-5-(4-hexyloxyphenyl)-1,3,4-oxadiazol
  参考文献：
  名称：

  Lora-Tomayo,M. et al., Bulletin de la Societe Chimique de France, 1964, p. 259 - 261

  摘要：

  DOI：

文献信息

• Synthesis and Characterization of Mesogenic 1,3,4-Oxadiazole Derivatives
  作者：J. Mahadeva、K. B. Umesha、K. M. L. Rai、Nagappa

  DOI：10.1080/15421400903054550

  日期：2009.9.3

  A synthesis of homologous series of mesogenic 2-amino-5-alkkloxyphenyl-1,3,4-oxadiazoles were prepared by the oxidative cyclisation of alkyloxybenzaldehyde semicarbozones (4) using chloramines-T (CAT) as osidate via intramolecular cycloaddition reaction. The reaction proceeds in better yield (75-85%) giving the product as solid with low melting points. The optical texture studies have been carried out using Leitz polarizing microscope to identify the liquid crystalline phases at different temperatures and it is found that the synthesized compounds exhibit nematic (N), smectic C (Sm C), smectic I (Sm I) and smectic G (Sm G) phases, sequentially at different temperatures.