7-(3-aminopropyl)-5,5-difluoro-1,3-dimethyl-5H-dipyrrolo[1,2-c:1',2'-f][1,3,2]diazaborinin-4-ium-5-uide | 1451009-83-8

• 英文名称: 7-(3-aminopropyl)-5,5-difluoro-1,3-dimethyl-5H-dipyrrolo[1,2-c:1',2'-f][1,3,2]diazaborinin-4-ium-5-uide
• 英文别名: 3-amino[4,4-difluoro-5,7-dimethyl-4-bora-3a,4a-diaza-s-indacene-3-yl]propane
• CAS: 1451009-83-8
• 化学式: C₁₄H₁₈BF₂N₃
• 分子量: 277.125
• InChiKey: DBIASJDZKPLHLX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  7-(3-aminopropyl)-5,5-difluoro-1,3-dimethyl-5H-dipyrrolo[1,2-c:1',2'-f][1,3,2]diazaborinin-4-ium-5-uide 、 苯甲酰氯 在 4-二甲氨基吡啶 、 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 以48%的产率得到7-(3-benzamidopropyl)-5,5-difluoro-1,3-dimethyl-5H-dipyrrolo[1,2-c:1',2'-f][1,3,2]diazaborinin-4-ium-5-uide
  参考文献：
  名称：

  Tunable BODIPY derivatives amenable to ‘click’ and peptide chemistry

  摘要：

  Novel azido- and amino-functionalised fluorescent probes based on the BODIPY framework have been developed. The probes can be easily and cheaply synthesised, exhibit the highly desirable BODIPY fluorescent properties, and are amenable to 'click' and peptide chemistry methodologies. These probes provide a stable and readily available tool amenable for the visualisation of both solution and solid supported events. (C) 2013 The Authors. Published by Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2013.05.037
• 作为产物：
  描述：

  7-(3-azidopropyl)-5,5-difluoro-1,3-dimethyl-5H-dipyrrolo[1,2-c:1',2'-f][1,3,2]diazaborinin-4-ium-5-uide 在 polymer bound triphenylphosphine 作用下， 以 四氢呋喃 为溶剂， 反应 4.0h， 以70%的产率得到7-(3-aminopropyl)-5,5-difluoro-1,3-dimethyl-5H-dipyrrolo[1,2-c:1',2'-f][1,3,2]diazaborinin-4-ium-5-uide
  参考文献：
  名称：

  Tunable BODIPY derivatives amenable to ‘click’ and peptide chemistry

  摘要：

  Novel azido- and amino-functionalised fluorescent probes based on the BODIPY framework have been developed. The probes can be easily and cheaply synthesised, exhibit the highly desirable BODIPY fluorescent properties, and are amenable to 'click' and peptide chemistry methodologies. These probes provide a stable and readily available tool amenable for the visualisation of both solution and solid supported events. (C) 2013 The Authors. Published by Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2013.05.037

文献信息

• WO2020127602A5
  申请人：——

  公开号：WO2020127602A5

  公开（公告）日：2022-12-20