[RuCl(Gly)(p-cymene)] | 850246-65-0

• 英文名称: [RuCl(Gly)(p-cymene)]
• 英文别名: [Ru(η⁶-p-cymene)(κ²N,O-glycinato)Cl]
• CAS: 850246-65-0
• 化学式: C₁₂H₁₈ClNO₂Ru
• 分子量: 344.803
• InChiKey: JWWUUONDAAAZSZ-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂ 、 sodium glycinate 在 sodium methylate 作用下， 以 甲醇 为溶剂， 生成 [RuCl(Gly)(p-cymene)]
  参考文献：
  名称：

  Arene ruthenium(II) azido complexes incorporating N⋂O chelate ligands: Synthesis, spectral studies and 1,3-dipolar-cycloaddition to a coordinated azide in ruthenium(II) compounds

  摘要：

  The arene ruthenium(II) azido compounds [{(p-cymene)Ru((NO)-O-boolean AND)N-3}] have been prepared by the reaction of [{(p-cymene)Ru(mu N-3)Cl}(2)] with the corresponding ligands. The ruthenium azido compounds [{(p-cymene)Ru((NO)-O-boolean AND)N-3}] undergo 1,3-dipolar additions with substituted alkynes at room temperature to give the (eta(6)-arene) ruthenium triazolato compounds [(p-cymene)Ru((NO)-O-boolean AND){N3C2(CO2R)(2)}]. The compounds were characterized on the basis of FTIR, NMR (H-1 and C-13) and the molecular structure of a representative compound has been established with the help of single crystal X-ray diffraction. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.poly.2013.10.032

文献信息

• Ruthenium Arene Complexes with α‐Aminoacidato Ligands: New Insights into Transfer Hydrogenation Reactions and Cytotoxic Behaviour
  作者：Lorenzo Biancalana、Issam Abdalghani、Federica Chiellini、Stefano Zacchini、Guido Pampaloni、Marcello Crucianelli、Fabio Marchetti

  DOI：10.1002/ejic.201800284

  日期：2018.7.13

  The RuII arene complexes [Ru(η6‐p‐cymene)(κ2N,O‐aa)Cl] (aa = l‐glutaminato, 1; l‐homoserinato, 2; l‐tyrosinato, 3; l‐serinato, 4; l‐prolinato, 5; trans‐4‐hydroxyl‐l‐prolinato, 6; l‐threoninato, 7; glycinato, 8) were synthesized in high yields by the reactions of [Ru(η6‐p‐cymene)Cl2]2 with aa/MOH (M = Na, K). The salt [Ru(η6‐p‐cymene)(κ2N,O‐l‐serinato)(PPh3)][CF3SO3], 9[CF3SO3], was prepared in 68 %

  在Ru II芳烃络合物的[Ru（η 6 - p -cymene）（κ 2 N，O -AA）CL]（AA = 1- glutaminato，1 ; 1- hoMOserinato，2 ; 1- tyrosinato，3 ; 1- serinato ，4 ; 1- prolinato，5 ;反式-4-羟基-1- prolinato，6 ; 1- threoninato，7 ; glycinato，8）在高产率的的[Ru的反应（合成η 6 - p‐cymene）Cl 2 ] 2与AA / MOH（M = Na，K）。盐的[Ru（η 6 - p -cymene）（κ 2 N，O -升-serinato）（PPH 3）] [CF 3 SO 3 ]，9 [CF 3 SO 3 ]，以68％产率制备从4和AgSO 3 CF 3 / PPh 3。所有产品均通过分析和光谱方法进行了充分表征，此外，还通过X射线衍射阐明了1和2的X射线结构。化合物1
• Self-Aggregation of Amino-Acidate Half-Sandwich Ruthenium(II) Complexes in Solution:  From Monomers to Nanoaggregates
  作者：Gianluca Ciancaleoni、Ilona Di Maio、Daniele Zuccaccia、Alceo Macchioni

  DOI：10.1021/om060904e

  日期：2007.1.1

  The aggregation tendency of [RuCl(AA)(Arene)] complexes (1, AA = amino acidate = Gly, Arene = p-cymene; 2, AA = Ala, Arene = p-cymene; 3, AA = N,N'-dimethyl-Gly, Arene = benzene; 3b, AA = N,N'-dimethyl-Gly, Arene = p-cymene; 3c, AA = N,N'-dimethyl-Gly, Arene = hexamethylbenzene; 4a, AA = t-Leu, Arene = benzene; 4b, AA = t-Leu, Arene = p-cymene; 4c, AA = t-Leu, Arene = hexamethylbenzene; 5, AA = alpha,alpha'-Me-2-Gly, Arene = p-cymene; 6, AA = alpha,alpha'-Ph-2-Gly, Arene = p-cymene; 7, AA = Pro, Arene = p-cymene) as a function of the concentration and solvent (CDCl3, CD2Cl2, acetone-d(6), and 2-propanol-d(8)) was investigated through diffusion NMR measurements. The equilibrium constant (K) and the standard variation of the free energy (Delta G degrees) for the aggregation process were determined by applying the Equal K self-aggregation model. The highest level of aggregation was observed for complexes 1, 2, and 4, bearing the NH2 moiety, which was involved in intermolecular H-bonding. Complex 2 formed aggregates with a hydrodynamic radius (r(H)) equal to 20.8 A in CDCl3 (Delta G degrees(296K) = -7.1 +/- 0.7 kcal mol(-1)) at a concentration of 124.9 mM, corresponding to an aggregation number (N) of 133. On the other hand, complex 3c did not show any tendency to aggregate (N = 1.1, 0.5 mM in CDCl3). The aggregation tendency decreased as the steric hindrance of arene (4a > 4b > 4c) and AA (1 approximate to 2 > 5 approximate to 4b > 6) and the polarity and proticity of the solvent increased. For complex 2, -Delta G degrees(kcal/mol) was 7.1 in CDCl3 (epsilon(r) = 4.81) > 5.6 in CD2Cl2 (epsilon(r) = 8.93) > 3.9 in acetone-d(6) (epsilon(r) = 20.56) > 3.0 in 2-propanol-d(8) (epsilon(r) = 19.92). While the two diastereoisomers of complexes 2 and 4b showed substantially the same tendency to self-aggregate, diastereoisomer (R-Ru, S-N, S-C)-7 showed a remarkably higher aggregation tendency than the other one [(S-Ru, S-N, S-C)-7] throughout the entire concentration range (1.4-178.0 mM) in CDCl3, indicating that a diastereoselective recognition process is occurring in solution [parallel to Delta(Delta G degrees(296K))parallel to = 1.8 +/- 0.5 kcal mol(-1)].