N-methyl-1-(4-imidazolyl)methanimine | 1374674-33-5

• 英文名称: N-methyl-1-(4-imidazolyl)methanimine
• 英文别名: 1-(1H-imidazol-5-yl)-N-methylmethanimine
• CAS: 1374674-33-5
• 化学式: C₅H₇N₃
• 分子量: 109.131
• InChiKey: YEONRDIKCFLKCH-UHFFFAOYSA-N

物化性质

• 沸点：
  323.2±15.0 °C(Predicted)
• 密度：
  1.12±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  8
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  41
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-methyl-1-(4-imidazolyl)methanimine 、 4-环氧丙烷氧基咔唑 以 乙醇 为溶剂， 反应 24.0h， 以50%的产率得到3-((9H-carbazol-4-yl)oxy)-1-(4-((methylimino)methyl)-1H-imidazole-1-yl)propan-2-ol
  参考文献：
  名称：

  Discovery of novel small molecule TLR4 inhibitors as potent anti-inflammatory agents

  摘要：

  Toll-like receptor 4 (TLR4) initiates innate immune response to release inflammatory cytokines and has been pathologically linked to variety of inflammatory diseases. Recently, we found that Carvedilol, as the classic anti-heart failure and anti-inflammatory clinic drug, could inhibit the TLR4 signaling in the TLR4 overexpressed cells. Herein, we have designed and synthesized a small library of novel Carvedilol derivatives and investigated their potential inhibitory activity. The results indicate that the most potent compound 8a (SMU-XY3) could effectively inhibited TLR4 protein and the LPS triggered alkaline phosphatase signaling in HEK-Blue hTLR4 cells. It down regulated the nitric oxide (NO) in both RAW264.7 cells and BV-2 microglial cells, in addition to blocking the TNF-alpha signaling in ex-vivo human peripheral blood mononuclear cells (PBMC). More interestingly, 8a shows higher affinity to hyperpolarization-activated cyclic nucleotide-gated 4 (HCN4) over HCN2, which probably indicates the new application of TLR4 inhibitor 8a in heart failure, coronary heart disease, and other inflammatory diseases. (C) 2018 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2018.05.033
• 作为产物：
  描述：

  4-咪唑甲醛 、 甲胺 以 甲醇 为溶剂， 反应 5.0h， 以93.8%的产率得到N-methyl-1-(4-imidazolyl)methanimine
  参考文献：
  名称：

  38 或 62 组件自组装的高对称协调笼

  摘要：

  通过自组装由大量子成分（> 50）组成的人工分子结构对化学家来说仍然是一项艰巨的挑战。38 组分 [14 Ni(2+) 和 24 N-methyl-1-(4-imidazolyl)methanimine] 在溶剂热条件下的反应可重复地导致高对称协调笼的形成。在涉及同步形成动态共价键和配位键的温和条件下，还可以通过自组装 62 种市售子组分（24 甲胺、24 4-甲酰基咪唑和 14 Ni(2+)）以高产率获得这种多面体笼. 客体分子（例如水、甲胺和甲醇）被随机限制在笼子中。

  DOI：

  10.1021/ja302142c

文献信息

• METAL NICKEL-IMIDAZOLATE CHIRAL NANO CLATHRATE COMPLEX AND PREPARATION METHOD THEREOF
  申请人：LI Dan

  公开号：US20140220349A1

  公开（公告）日：2014-08-07

  The present invention discloses a metal nickel-imidazolate chiral nano clathrate complex and preparation method thereof. The new type of metal nickel-imidazolate chiral nano clathrate complex of the present invention has the following chemical formula: [Ni 14 (Im) 24 ].4NO 3 , in which Im is N-1-methyl-(4-imidazole) methylene imine. The complex can be obtained directly from a reaction of starting materials or prepared through first initiating a reaction between the compound ligand Im and a nickel salt under solvothermal conditions, and the complex obtained is of higher purity. The nano clathrate complex of the present invention has single chirality, and higher thermal stability, and thus has potential application in chiral catalytic materials.

  本发明公开了一种金属镍-咪唑醛酸盐手性纳米笼络合物及其制备方法。本发明的新型金属镍-咪唑醛酸盐手性纳米笼络合物具有以下化学式：[Ni14(Im)24].4NO3，其中Im为N-1-甲基-(4-咪唑)亚甲基亚胺。该络合物可直接从起始材料的反应中获得，或通过首先在溶剂热条件下引发化合物配体Im与镍盐之间的反应来制备，所得到的复合物纯度较高。本发明的纳米笼络合物具有单一手性和较高的热稳定性，因此在手性催化材料中具有潜在应用价值。
• 白金錯体およびそれを含む発光材料
  申请人：国立大学法人大阪大学

  公开号：JP2015172007A

  公开（公告）日：2015-10-01

  【課題】固体であって、発光強度が強い燐光性発光材料の提供。【解決手段】式（Ｉ）又は式（ＩＩ）で表される白金錯体及びそれを含む発光材料。【選択図】なし

  【问题】提供一种固体、发光强度强的磷光性发光材料。【解决方法】包含由式（I）或式（II）表示的铂络合物的发光材料。【选择图】无