| 1345015-22-6

• CAS: 1345015-22-6
• 化学式: C₃₈H₅₃N₂NiP
• 分子量: 627.516
• InChiKey: BPHAUHOLTYPPNA-MHZTUVSFSA-N

反应信息

• 作为产物：
  描述：

  bis(1,5-cyclooctadiene)nickel (0) 、 苯甲腈 、 2,3-二甲基-1,3-丁二烯 、 三环己基膦 以 甲苯 为溶剂， 以38%的产率得到
  参考文献：
  名称：

  Nickel-Catalyzed Dehydrogenative [4 + 2] Cycloaddition of 1,3-Dienes with Nitriles

  摘要：

  Pyridines, which comprise one of the most important classes of the six-membered heterocyclic compounds, are widely distributed in nature, and the transition-metal-catalyzed [2 + 2 + 2] cycloaddition reaction of two alkynes and a nitrile is one of the most powerful methods for preparing versatile, highly substituted pyridine derivatives. However, the lack of chemo- and regioselectivity is still a crucial issue associated with fully intermolecular [2 + 2 + 2] cycloaddition. The present study developed the Ni(0)-catalyzed intermolecular dehydrogenative [4 + 2] cycloaddition reaction of 1,3-butadienes with nitrites to give a variety of pyridines regioselectively.

  DOI：

  10.1021/ja208162w