trans-[(MeH2N)2Pt(1-methylcytosinato)2PdCl]NO3 | 147893-54-7

• 英文名称: trans-[(MeH2N)2Pt(1-methylcytosinato)2PdCl]NO3
• CAS: 147893-54-7
• 化学式: C₁₂H₂₂ClN₈O₂PdPt*NO₃
• 分子量: 709.317
• InChiKey: XOTHSLPNSQKURD-UHFFFAOYSA-K

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  trans-[(MeH2N)2Pt(1-methylcytosinato)2PdCl]NO3 在 N-acetyl-L-lysine, fully protonated form 作用下， 以 重水 为溶剂， 生成 [(MeH₂N)2Pt(1-methylcytosinato)2Pd(N-acetyl-L-lysine)⁽²⁺⁾]
  参考文献：
  名称：

  Spectroscopic and potentiometric studies on the interaction of trans-[(MeH₂N)₂Pt(mcyt)₂PdCl]NO₃(mcyt = 1-methylcytosinate) with derivatives of amino acids

  摘要：

  The interaction of the mixed-metal complex trans-[(MeH(2)N)(2)Pt(mcyt)(2)PdCl]NO3 (mcyt = 1-methyl-cytosinate) with various derivatives of amino acids mimicking the side-chain metal binding sites of proteins were studied by H-1 NMR, spectrophotometric and potentiometric methods. The derivatives included N-acetylamino acids (N-acetyl-methionine, -cysteine -lysine, -histidine and -histamine), amino acids (glycine and methionine) and dipeptides (Gly-Met and Gly-Lys). The coordination of independent thioether, amino or imidazole nitrogen side-chain donor groups resulted in the formation of stable mono- or di-nuclear adducts. The formation of dinuclear complexes was characteristic of dipeptides and N-acetyl-histidine and -histamine. The existence of linkage isomers was demonstrated in the latter case, the Pd-N(3) (imidazole) isomers being more favoured. The possibility of stable chelate formation with palladium(ii) (e.g. S,O for N-acetylcysteine and S,N for methionine) significantly enhanced the decomposition of the mixed-metal complex, leading to trans[Pt(NH(2)Me)(2)(Hmcyt)(2)](2+).

  DOI：

  10.1039/dt9950000489