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trans-[(MeH2N)2Pt(1-methylcytosinato)2PdCl]NO3 | 147893-54-7

中文名称
——
中文别名
——
英文名称
trans-[(MeH2N)2Pt(1-methylcytosinato)2PdCl]NO3
英文别名
——
trans-[(MeH2N)2Pt(1-methylcytosinato)2PdCl]NO3化学式
CAS
147893-54-7
化学式
C12H22ClN8O2PdPt*NO3
mdl
——
分子量
709.317
InChiKey
XOTHSLPNSQKURD-UHFFFAOYSA-K
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    None
  • 重原子数:
    None
  • 可旋转键数:
    None
  • 环数:
    None
  • sp3杂化的碳原子比例:
    None
  • 拓扑面积:
    None
  • 氢给体数:
    None
  • 氢受体数:
    None

反应信息

  • 作为反应物:
    描述:
    trans-[(MeH2N)2Pt(1-methylcytosinato)2PdCl]NO3 在 N-acetyl-L-lysine, fully protonated form 作用下, 以 重水 为溶剂, 生成 [(MeH2N)2Pt(1-methylcytosinato)2Pd(N-acetyl-L-lysine)(2+)]
    参考文献:
    名称:
    Spectroscopic and potentiometric studies on the interaction of trans-[(MeH2N)2Pt(mcyt)2PdCl]NO3(mcyt = 1-methylcytosinate) with derivatives of amino acids
    摘要:
    The interaction of the mixed-metal complex trans-[(MeH(2)N)(2)Pt(mcyt)(2)PdCl]NO3 (mcyt = 1-methyl-cytosinate) with various derivatives of amino acids mimicking the side-chain metal binding sites of proteins were studied by H-1 NMR, spectrophotometric and potentiometric methods. The derivatives included N-acetylamino acids (N-acetyl-methionine, -cysteine -lysine, -histidine and -histamine), amino acids (glycine and methionine) and dipeptides (Gly-Met and Gly-Lys). The coordination of independent thioether, amino or imidazole nitrogen side-chain donor groups resulted in the formation of stable mono- or di-nuclear adducts. The formation of dinuclear complexes was characteristic of dipeptides and N-acetyl-histidine and -histamine. The existence of linkage isomers was demonstrated in the latter case, the Pd-N(3) (imidazole) isomers being more favoured. The possibility of stable chelate formation with palladium(ii) (e.g. S,O for N-acetylcysteine and S,N for methionine) significantly enhanced the decomposition of the mixed-metal complex, leading to trans[Pt(NH(2)Me)(2)(Hmcyt)(2)](2+).
    DOI:
    10.1039/dt9950000489
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